Cargando…

The Serine Protease CD26/DPP4 in Non-Transformed and Malignant T Cells

SIMPLE SUMMARY: The transmembrane serine protease CD26/Dipeptidylpeptidase 4 modulates T-cell activation, proliferation, and effector function. Due to their remarkable tumoricidal properties CD26-positive T cells are considered promising candidates for T cell-based immunotherapies while in cutaneous...

Descripción completa

Detalles Bibliográficos
Autores principales: Chitadze, Guranda, Wehkamp, Ulrike, Janssen, Ottmar, Brüggemann, Monika, Lettau, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657226/
https://www.ncbi.nlm.nih.gov/pubmed/34885056
http://dx.doi.org/10.3390/cancers13235947
_version_ 1784612462523318272
author Chitadze, Guranda
Wehkamp, Ulrike
Janssen, Ottmar
Brüggemann, Monika
Lettau, Marcus
author_facet Chitadze, Guranda
Wehkamp, Ulrike
Janssen, Ottmar
Brüggemann, Monika
Lettau, Marcus
author_sort Chitadze, Guranda
collection PubMed
description SIMPLE SUMMARY: The transmembrane serine protease CD26/Dipeptidylpeptidase 4 modulates T-cell activation, proliferation, and effector function. Due to their remarkable tumoricidal properties CD26-positive T cells are considered promising candidates for T cell-based immunotherapies while in cutaneous T cell lymphoma CD26/DPP4 expression patterns are established markers for diagnosis and possibly prognosis. With a focus on T cells, we review current knowledge on the regulation of CD26/DPP4 expression and release, its implication in T-cell effector function and the suitability CD26/DPP4 as a diagnostic and/or prognostic factor in T-cell malignancies. ABSTRACT: CD26/Dipeptidylpeptidase 4 is a transmembrane serine protease that cleaves off N-terminal dipeptides. CD26/DPP4 is expressed on several immune cell types including T and NK cells, dendritic cells, and activated B cells. A catalytically active soluble form of CD26/DPP4 can be released from the plasma membrane. Given its wide array of substrates and interaction partners CD26/DPP4 has been implicated in numerous biological processes and effects can be dependent or independent of its enzymatic activity and are exerted by the transmembrane protein and/or the soluble form. CD26/DPP4 has been implicated in the modulation of T-cell activation and proliferation and CD26/DPP4-positive T cells are characterized by remarkable anti-tumor properties rendering them interesting candidates for T cell-based immunotherapies. Moreover, especially in cutaneous T-cell lymphoma CD26/DPP4 expression patterns emerged as an established marker for diagnosis and treatment monitoring. Surprisingly, besides a profound knowledge on substrates, interaction partners, and associated signal transduction pathways, the precise role of CD26/DPP4 for T cell-based immune responses is only partially understood.
format Online
Article
Text
id pubmed-8657226
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86572262021-12-10 The Serine Protease CD26/DPP4 in Non-Transformed and Malignant T Cells Chitadze, Guranda Wehkamp, Ulrike Janssen, Ottmar Brüggemann, Monika Lettau, Marcus Cancers (Basel) Review SIMPLE SUMMARY: The transmembrane serine protease CD26/Dipeptidylpeptidase 4 modulates T-cell activation, proliferation, and effector function. Due to their remarkable tumoricidal properties CD26-positive T cells are considered promising candidates for T cell-based immunotherapies while in cutaneous T cell lymphoma CD26/DPP4 expression patterns are established markers for diagnosis and possibly prognosis. With a focus on T cells, we review current knowledge on the regulation of CD26/DPP4 expression and release, its implication in T-cell effector function and the suitability CD26/DPP4 as a diagnostic and/or prognostic factor in T-cell malignancies. ABSTRACT: CD26/Dipeptidylpeptidase 4 is a transmembrane serine protease that cleaves off N-terminal dipeptides. CD26/DPP4 is expressed on several immune cell types including T and NK cells, dendritic cells, and activated B cells. A catalytically active soluble form of CD26/DPP4 can be released from the plasma membrane. Given its wide array of substrates and interaction partners CD26/DPP4 has been implicated in numerous biological processes and effects can be dependent or independent of its enzymatic activity and are exerted by the transmembrane protein and/or the soluble form. CD26/DPP4 has been implicated in the modulation of T-cell activation and proliferation and CD26/DPP4-positive T cells are characterized by remarkable anti-tumor properties rendering them interesting candidates for T cell-based immunotherapies. Moreover, especially in cutaneous T-cell lymphoma CD26/DPP4 expression patterns emerged as an established marker for diagnosis and treatment monitoring. Surprisingly, besides a profound knowledge on substrates, interaction partners, and associated signal transduction pathways, the precise role of CD26/DPP4 for T cell-based immune responses is only partially understood. MDPI 2021-11-26 /pmc/articles/PMC8657226/ /pubmed/34885056 http://dx.doi.org/10.3390/cancers13235947 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chitadze, Guranda
Wehkamp, Ulrike
Janssen, Ottmar
Brüggemann, Monika
Lettau, Marcus
The Serine Protease CD26/DPP4 in Non-Transformed and Malignant T Cells
title The Serine Protease CD26/DPP4 in Non-Transformed and Malignant T Cells
title_full The Serine Protease CD26/DPP4 in Non-Transformed and Malignant T Cells
title_fullStr The Serine Protease CD26/DPP4 in Non-Transformed and Malignant T Cells
title_full_unstemmed The Serine Protease CD26/DPP4 in Non-Transformed and Malignant T Cells
title_short The Serine Protease CD26/DPP4 in Non-Transformed and Malignant T Cells
title_sort serine protease cd26/dpp4 in non-transformed and malignant t cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657226/
https://www.ncbi.nlm.nih.gov/pubmed/34885056
http://dx.doi.org/10.3390/cancers13235947
work_keys_str_mv AT chitadzeguranda theserineproteasecd26dpp4innontransformedandmalignanttcells
AT wehkampulrike theserineproteasecd26dpp4innontransformedandmalignanttcells
AT janssenottmar theserineproteasecd26dpp4innontransformedandmalignanttcells
AT bruggemannmonika theserineproteasecd26dpp4innontransformedandmalignanttcells
AT lettaumarcus theserineproteasecd26dpp4innontransformedandmalignanttcells
AT chitadzeguranda serineproteasecd26dpp4innontransformedandmalignanttcells
AT wehkampulrike serineproteasecd26dpp4innontransformedandmalignanttcells
AT janssenottmar serineproteasecd26dpp4innontransformedandmalignanttcells
AT bruggemannmonika serineproteasecd26dpp4innontransformedandmalignanttcells
AT lettaumarcus serineproteasecd26dpp4innontransformedandmalignanttcells