Mitochondrial Plasticity Promotes Resistance to Sorafenib and Vulnerability to STAT3 Inhibition in Human Hepatocellular Carcinoma

SIMPLE SUMMARY: Enhanced expression of mitochondrial ribosomal proteins and marked reprogramming of the mitochondrial network are associated with sorafenib resistance in human cell lines and hepatocarcinoma patients, providing novel actionable targets for increasing therapeutic efficacy. ABSTRACT: T...

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Detalles Bibliográficos
Autores principales: Pandit, Shusil K., Sandrini, Giada, Merulla, Jessica, Nobili, Valentina, Wang, Xin, Zangari, Alessia, Rinaldi, Andrea, Shinde, Dheeraj, Carbone, Giuseppina M., Catapano, Carlo V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657239/
https://www.ncbi.nlm.nih.gov/pubmed/34885140
http://dx.doi.org/10.3390/cancers13236029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657239/
https://www.ncbi.nlm.nih.gov/pubmed/34885140
http://dx.doi.org/10.3390/cancers13236029

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