Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through α(2A) Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice

Dexmedetomidine (DEX), a selective α(2) adrenergic receptor (AR) agonist, is commonly used as a sedative drug during critical illness. In the present study, we explored a novel accelerative effect of DEX on cardiac fibroblast (CF) differentiation mediated by LPS and clarified its potential mechanism...

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Detalles Bibliográficos
Autores principales: Liao, Jia, Li, Kaiying, Su, Xingyu, Chen, Yihua, Wang, Yingwei, Tang, Xiangxu, Xing, Yun, Xu, Yaqian, Dai, Xiaomeng, Teng, Jiashuo, Li, Hongmei, Wang, Huadong, Lv, Xiuxiu, Wang, Yiyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657501/
https://www.ncbi.nlm.nih.gov/pubmed/34884552
http://dx.doi.org/10.3390/ijms222312749

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