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Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors

The advent of new insights into phosphate metabolism must urge the endocrinologist to rethink the pathophysiology of widespread disorders, such as primary hyperparathyroidism, and also of rarer endocrine metabolic bone diseases, such as hypoparathyroidism and tumor-induced hypophosphatemia. These ra...

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Autores principales: Zavatta, Guido, Altieri, Paola, Vandi, Giulia, Vicennati, Valentina, Pagotto, Uberto, Vescini, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657508/
https://www.ncbi.nlm.nih.gov/pubmed/34884774
http://dx.doi.org/10.3390/ijms222312975
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author Zavatta, Guido
Altieri, Paola
Vandi, Giulia
Vicennati, Valentina
Pagotto, Uberto
Vescini, Fabio
author_facet Zavatta, Guido
Altieri, Paola
Vandi, Giulia
Vicennati, Valentina
Pagotto, Uberto
Vescini, Fabio
author_sort Zavatta, Guido
collection PubMed
description The advent of new insights into phosphate metabolism must urge the endocrinologist to rethink the pathophysiology of widespread disorders, such as primary hyperparathyroidism, and also of rarer endocrine metabolic bone diseases, such as hypoparathyroidism and tumor-induced hypophosphatemia. These rare diseases of mineral metabolism have been and will be a precious source of new information about phosphate and other minerals in the coming years. The parathyroid glands, the kidneys, and the intestine are the main organs affecting phosphate levels in the blood and urine. Parathyroid disorders, renal tubule defects, or phosphatonin-producing tumors might be unveiled from alterations of such a simple and inexpensive mineral as serum phosphate. This review will present all these disorders from a ‘phosphate perspective’.
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spelling pubmed-86575082021-12-10 Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors Zavatta, Guido Altieri, Paola Vandi, Giulia Vicennati, Valentina Pagotto, Uberto Vescini, Fabio Int J Mol Sci Review The advent of new insights into phosphate metabolism must urge the endocrinologist to rethink the pathophysiology of widespread disorders, such as primary hyperparathyroidism, and also of rarer endocrine metabolic bone diseases, such as hypoparathyroidism and tumor-induced hypophosphatemia. These rare diseases of mineral metabolism have been and will be a precious source of new information about phosphate and other minerals in the coming years. The parathyroid glands, the kidneys, and the intestine are the main organs affecting phosphate levels in the blood and urine. Parathyroid disorders, renal tubule defects, or phosphatonin-producing tumors might be unveiled from alterations of such a simple and inexpensive mineral as serum phosphate. This review will present all these disorders from a ‘phosphate perspective’. MDPI 2021-11-30 /pmc/articles/PMC8657508/ /pubmed/34884774 http://dx.doi.org/10.3390/ijms222312975 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zavatta, Guido
Altieri, Paola
Vandi, Giulia
Vicennati, Valentina
Pagotto, Uberto
Vescini, Fabio
Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors
title Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors
title_full Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors
title_fullStr Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors
title_full_unstemmed Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors
title_short Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors
title_sort phosphate metabolism and pathophysiology in parathyroid disorders and endocrine tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657508/
https://www.ncbi.nlm.nih.gov/pubmed/34884774
http://dx.doi.org/10.3390/ijms222312975
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