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Telmisartan Attenuates Kanamycin-Induced Ototoxicity in Rats
Telmisartan (TM) has been proposed to relieve inflammatory responses by modulating peroxisome proliferator activator receptor-γ (PPARγ) signaling. This study aimed to investigate the protective effects of TM on kanamycin(KM)-induced ototoxicity in rats. Forty-eight, 8-week-old female Sprague Dawley...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657567/ https://www.ncbi.nlm.nih.gov/pubmed/34884516 http://dx.doi.org/10.3390/ijms222312716 |
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author | Lee, Chang Ho Lee, So Min Kim, So Young |
author_facet | Lee, Chang Ho Lee, So Min Kim, So Young |
author_sort | Lee, Chang Ho |
collection | PubMed |
description | Telmisartan (TM) has been proposed to relieve inflammatory responses by modulating peroxisome proliferator activator receptor-γ (PPARγ) signaling. This study aimed to investigate the protective effects of TM on kanamycin(KM)-induced ototoxicity in rats. Forty-eight, 8-week-old female Sprague Dawley rats were divided into four groups: (1) control group, (2) TM group, (3) KM group, and (4) TM + KM group. Auditory brainstem response was measured. The histology of the cochlea was examined. The protein expression levels of angiotensin-converting enzyme 2 (ACE2), HO1, and PPARγ were measured by Western blotting. The auditory threshold shifts at 4, 8, 16, and 32 kHz were lower in the TM + KM group than in the KM group (all p < 0.05). The loss of cochlear outer hair cells and spiral ganglial cells was lower in the TM + KM group than in the KM group. The protein expression levels of ACE2, PPARγ, and HO1 were higher in the KM group than in the control group (all p < 0.05). The TM + KM group showed lower expression levels of PPARγ and HO1 than the KM group.TM protected the cochlea from KM-induced injuries in rats. TM preserved hearing levels and attenuated the increase in PPARγ and HO1 expression levels in KM-exposed rat cochleae. |
format | Online Article Text |
id | pubmed-8657567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86575672021-12-10 Telmisartan Attenuates Kanamycin-Induced Ototoxicity in Rats Lee, Chang Ho Lee, So Min Kim, So Young Int J Mol Sci Article Telmisartan (TM) has been proposed to relieve inflammatory responses by modulating peroxisome proliferator activator receptor-γ (PPARγ) signaling. This study aimed to investigate the protective effects of TM on kanamycin(KM)-induced ototoxicity in rats. Forty-eight, 8-week-old female Sprague Dawley rats were divided into four groups: (1) control group, (2) TM group, (3) KM group, and (4) TM + KM group. Auditory brainstem response was measured. The histology of the cochlea was examined. The protein expression levels of angiotensin-converting enzyme 2 (ACE2), HO1, and PPARγ were measured by Western blotting. The auditory threshold shifts at 4, 8, 16, and 32 kHz were lower in the TM + KM group than in the KM group (all p < 0.05). The loss of cochlear outer hair cells and spiral ganglial cells was lower in the TM + KM group than in the KM group. The protein expression levels of ACE2, PPARγ, and HO1 were higher in the KM group than in the control group (all p < 0.05). The TM + KM group showed lower expression levels of PPARγ and HO1 than the KM group.TM protected the cochlea from KM-induced injuries in rats. TM preserved hearing levels and attenuated the increase in PPARγ and HO1 expression levels in KM-exposed rat cochleae. MDPI 2021-11-24 /pmc/articles/PMC8657567/ /pubmed/34884516 http://dx.doi.org/10.3390/ijms222312716 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Chang Ho Lee, So Min Kim, So Young Telmisartan Attenuates Kanamycin-Induced Ototoxicity in Rats |
title | Telmisartan Attenuates Kanamycin-Induced Ototoxicity in Rats |
title_full | Telmisartan Attenuates Kanamycin-Induced Ototoxicity in Rats |
title_fullStr | Telmisartan Attenuates Kanamycin-Induced Ototoxicity in Rats |
title_full_unstemmed | Telmisartan Attenuates Kanamycin-Induced Ototoxicity in Rats |
title_short | Telmisartan Attenuates Kanamycin-Induced Ototoxicity in Rats |
title_sort | telmisartan attenuates kanamycin-induced ototoxicity in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657567/ https://www.ncbi.nlm.nih.gov/pubmed/34884516 http://dx.doi.org/10.3390/ijms222312716 |
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