Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish (Danio rerio)

The mechanisms of resistance to antidepressant drugs is a key and still unresolved problem of psychopharmacology. Serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) play a key role in the therapeutic effect of many antidepressants. Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzy...

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Detalles Bibliográficos
Autores principales: Evsiukova, Valentina S., Bazovkina, Daria, Bazhenova, Ekaterina, Kulikova, Elizabeth A., Kulikov, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657639/
https://www.ncbi.nlm.nih.gov/pubmed/34884655
http://dx.doi.org/10.3390/ijms222312851

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