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Mitochondrial Transport in Glycolysis and Gluconeogenesis: Achievements and Perspectives

Some metabolic pathways involve two different cell components, for instance, cytosol and mitochondria, with metabolites traffic occurring from cytosol to mitochondria and vice versa, as seen in both glycolysis and gluconeogenesis. However, the knowledge on the role of mitochondrial transport within...

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Detalles Bibliográficos
Autores principales: Passarella, Salvatore, Schurr, Avital, Portincasa, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657705/
https://www.ncbi.nlm.nih.gov/pubmed/34884425
http://dx.doi.org/10.3390/ijms222312620
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author Passarella, Salvatore
Schurr, Avital
Portincasa, Piero
author_facet Passarella, Salvatore
Schurr, Avital
Portincasa, Piero
author_sort Passarella, Salvatore
collection PubMed
description Some metabolic pathways involve two different cell components, for instance, cytosol and mitochondria, with metabolites traffic occurring from cytosol to mitochondria and vice versa, as seen in both glycolysis and gluconeogenesis. However, the knowledge on the role of mitochondrial transport within these two glucose metabolic pathways remains poorly understood, due to controversial information available in published literature. In what follows, we discuss achievements, knowledge gaps, and perspectives on the role of mitochondrial transport in glycolysis and gluconeogenesis. We firstly describe the experimental approaches for quick and easy investigation of mitochondrial transport, with respect to cell metabolic diversity. In addition, we depict the mitochondrial shuttles by which NADH formed in glycolysis is oxidized, the mitochondrial transport of phosphoenolpyruvate in the light of the occurrence of the mitochondrial pyruvate kinase, and the mitochondrial transport and metabolism of L-lactate due to the L-lactate translocators and to the mitochondrial L-lactate dehydrogenase located in the inner mitochondrial compartment.
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spelling pubmed-86577052021-12-10 Mitochondrial Transport in Glycolysis and Gluconeogenesis: Achievements and Perspectives Passarella, Salvatore Schurr, Avital Portincasa, Piero Int J Mol Sci Review Some metabolic pathways involve two different cell components, for instance, cytosol and mitochondria, with metabolites traffic occurring from cytosol to mitochondria and vice versa, as seen in both glycolysis and gluconeogenesis. However, the knowledge on the role of mitochondrial transport within these two glucose metabolic pathways remains poorly understood, due to controversial information available in published literature. In what follows, we discuss achievements, knowledge gaps, and perspectives on the role of mitochondrial transport in glycolysis and gluconeogenesis. We firstly describe the experimental approaches for quick and easy investigation of mitochondrial transport, with respect to cell metabolic diversity. In addition, we depict the mitochondrial shuttles by which NADH formed in glycolysis is oxidized, the mitochondrial transport of phosphoenolpyruvate in the light of the occurrence of the mitochondrial pyruvate kinase, and the mitochondrial transport and metabolism of L-lactate due to the L-lactate translocators and to the mitochondrial L-lactate dehydrogenase located in the inner mitochondrial compartment. MDPI 2021-11-23 /pmc/articles/PMC8657705/ /pubmed/34884425 http://dx.doi.org/10.3390/ijms222312620 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Passarella, Salvatore
Schurr, Avital
Portincasa, Piero
Mitochondrial Transport in Glycolysis and Gluconeogenesis: Achievements and Perspectives
title Mitochondrial Transport in Glycolysis and Gluconeogenesis: Achievements and Perspectives
title_full Mitochondrial Transport in Glycolysis and Gluconeogenesis: Achievements and Perspectives
title_fullStr Mitochondrial Transport in Glycolysis and Gluconeogenesis: Achievements and Perspectives
title_full_unstemmed Mitochondrial Transport in Glycolysis and Gluconeogenesis: Achievements and Perspectives
title_short Mitochondrial Transport in Glycolysis and Gluconeogenesis: Achievements and Perspectives
title_sort mitochondrial transport in glycolysis and gluconeogenesis: achievements and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657705/
https://www.ncbi.nlm.nih.gov/pubmed/34884425
http://dx.doi.org/10.3390/ijms222312620
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