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Targeting Mediators of Inflammation in Heart Failure: A Short Synthesis of Experimental and Clinical Results
Inflammation has emerged as an important contributor to heart failure (HF) development and progression. Current research data highlight the diversity of immune cells, proteins, and signaling pathways involved in the pathogenesis and perpetuation of heart failure. Chronic inflammation is a major card...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657742/ https://www.ncbi.nlm.nih.gov/pubmed/34884857 http://dx.doi.org/10.3390/ijms222313053 |
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author | Szabo, Timea Magdolna Frigy, Attila Nagy, Előd Ernő |
author_facet | Szabo, Timea Magdolna Frigy, Attila Nagy, Előd Ernő |
author_sort | Szabo, Timea Magdolna |
collection | PubMed |
description | Inflammation has emerged as an important contributor to heart failure (HF) development and progression. Current research data highlight the diversity of immune cells, proteins, and signaling pathways involved in the pathogenesis and perpetuation of heart failure. Chronic inflammation is a major cardiovascular risk factor. Proinflammatory signaling molecules in HF initiate vicious cycles altering mitochondrial function and perturbing calcium homeostasis, therefore affecting myocardial contractility. Specific anti-inflammatory treatment represents a novel approach to prevent and slow HF progression. This review provides an update on the putative roles of inflammatory mediators involved in heart failure (tumor necrosis factor-alpha; interleukin 1, 6, 17, 18, 33) and currently available biological and non-biological therapy options targeting the aforementioned mediators and signaling pathways. We also highlight new treatment approaches based on the latest clinical and experimental research. |
format | Online Article Text |
id | pubmed-8657742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86577422021-12-10 Targeting Mediators of Inflammation in Heart Failure: A Short Synthesis of Experimental and Clinical Results Szabo, Timea Magdolna Frigy, Attila Nagy, Előd Ernő Int J Mol Sci Review Inflammation has emerged as an important contributor to heart failure (HF) development and progression. Current research data highlight the diversity of immune cells, proteins, and signaling pathways involved in the pathogenesis and perpetuation of heart failure. Chronic inflammation is a major cardiovascular risk factor. Proinflammatory signaling molecules in HF initiate vicious cycles altering mitochondrial function and perturbing calcium homeostasis, therefore affecting myocardial contractility. Specific anti-inflammatory treatment represents a novel approach to prevent and slow HF progression. This review provides an update on the putative roles of inflammatory mediators involved in heart failure (tumor necrosis factor-alpha; interleukin 1, 6, 17, 18, 33) and currently available biological and non-biological therapy options targeting the aforementioned mediators and signaling pathways. We also highlight new treatment approaches based on the latest clinical and experimental research. MDPI 2021-12-02 /pmc/articles/PMC8657742/ /pubmed/34884857 http://dx.doi.org/10.3390/ijms222313053 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Szabo, Timea Magdolna Frigy, Attila Nagy, Előd Ernő Targeting Mediators of Inflammation in Heart Failure: A Short Synthesis of Experimental and Clinical Results |
title | Targeting Mediators of Inflammation in Heart Failure: A Short Synthesis of Experimental and Clinical Results |
title_full | Targeting Mediators of Inflammation in Heart Failure: A Short Synthesis of Experimental and Clinical Results |
title_fullStr | Targeting Mediators of Inflammation in Heart Failure: A Short Synthesis of Experimental and Clinical Results |
title_full_unstemmed | Targeting Mediators of Inflammation in Heart Failure: A Short Synthesis of Experimental and Clinical Results |
title_short | Targeting Mediators of Inflammation in Heart Failure: A Short Synthesis of Experimental and Clinical Results |
title_sort | targeting mediators of inflammation in heart failure: a short synthesis of experimental and clinical results |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657742/ https://www.ncbi.nlm.nih.gov/pubmed/34884857 http://dx.doi.org/10.3390/ijms222313053 |
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