Cargando…
Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD
Thyroid hormones control lipid metabolism by exhibiting specific effects on the liver and adipose tissue in a coordinated manner. Different diseases of the thyroid gland can result in hypothyroidism. Hypothyroidism is frequently associated with dyslipidemia. Hypothyroidism-associated dyslipidemia su...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657790/ https://www.ncbi.nlm.nih.gov/pubmed/34884625 http://dx.doi.org/10.3390/ijms222312797 |
_version_ | 1784612583068663808 |
---|---|
author | Mavromati, Maria Jornayvaz, François R. |
author_facet | Mavromati, Maria Jornayvaz, François R. |
author_sort | Mavromati, Maria |
collection | PubMed |
description | Thyroid hormones control lipid metabolism by exhibiting specific effects on the liver and adipose tissue in a coordinated manner. Different diseases of the thyroid gland can result in hypothyroidism. Hypothyroidism is frequently associated with dyslipidemia. Hypothyroidism-associated dyslipidemia subsequently results in intrahepatic accumulation of fat, leading to nonalcoholic fatty liver disease (NAFLD), which leads to the development of hepatic insulin resistance. The prevalence of NAFLD in the western world is increasing, and evidence of its association with hypothyroidism is accumulating. Since hypothyroidism has been identified as a modifiable risk factor of NAFLD and recent data provides evidence that selective thyroid hormone receptor β (THR-β) agonists are effective in the treatment of dyslipidemia and NAFLD, interest in potential therapeutic options for NAFLD targeting these receptors is growing. In this review, we summarize current knowledge regarding clinical and molecular data exploring the association of hypothyroidism, dyslipidemia and NAFLD. |
format | Online Article Text |
id | pubmed-8657790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86577902021-12-10 Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD Mavromati, Maria Jornayvaz, François R. Int J Mol Sci Review Thyroid hormones control lipid metabolism by exhibiting specific effects on the liver and adipose tissue in a coordinated manner. Different diseases of the thyroid gland can result in hypothyroidism. Hypothyroidism is frequently associated with dyslipidemia. Hypothyroidism-associated dyslipidemia subsequently results in intrahepatic accumulation of fat, leading to nonalcoholic fatty liver disease (NAFLD), which leads to the development of hepatic insulin resistance. The prevalence of NAFLD in the western world is increasing, and evidence of its association with hypothyroidism is accumulating. Since hypothyroidism has been identified as a modifiable risk factor of NAFLD and recent data provides evidence that selective thyroid hormone receptor β (THR-β) agonists are effective in the treatment of dyslipidemia and NAFLD, interest in potential therapeutic options for NAFLD targeting these receptors is growing. In this review, we summarize current knowledge regarding clinical and molecular data exploring the association of hypothyroidism, dyslipidemia and NAFLD. MDPI 2021-11-26 /pmc/articles/PMC8657790/ /pubmed/34884625 http://dx.doi.org/10.3390/ijms222312797 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mavromati, Maria Jornayvaz, François R. Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD |
title | Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD |
title_full | Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD |
title_fullStr | Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD |
title_full_unstemmed | Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD |
title_short | Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD |
title_sort | hypothyroidism-associated dyslipidemia: potential molecular mechanisms leading to nafld |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657790/ https://www.ncbi.nlm.nih.gov/pubmed/34884625 http://dx.doi.org/10.3390/ijms222312797 |
work_keys_str_mv | AT mavromatimaria hypothyroidismassociateddyslipidemiapotentialmolecularmechanismsleadingtonafld AT jornayvazfrancoisr hypothyroidismassociateddyslipidemiapotentialmolecularmechanismsleadingtonafld |