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Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation

Calcium influx through plasma membrane calcium release-activated calcium (CRAC) channels, which are formed of hexamers of Orai1, is a potent trigger for many important biological processes, most notably in T cell-mediated immunity. Through a bioinformatics-led cell biological screen, we have identif...

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Detalles Bibliográficos
Autores principales:	Grieve, Adam G., Yeh, Yi-Chun, Chang, Yu-Fen, Huang, Hsin-Yi, Zarcone, Lucrezia, Breuning, Johannes, Johnson, Nicholas, Stříšovský, Kvido, Brown, Marion H., Parekh, Anant B., Freeman, Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657799/ https://www.ncbi.nlm.nih.gov/pubmed/34800360 http://dx.doi.org/10.1016/j.molcel.2021.10.025

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