Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy

Reprogramming brain-resident glial cells into clinically relevant induced neurons (iNs) is an emerging strategy toward replacing lost neurons and restoring lost brain functions. A fundamental question is now whether iNs can promote functional recovery in pathological contexts. We addressed this ques...

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Detalles Bibliográficos
Autores principales: Lentini, Célia, d’Orange, Marie, Marichal, Nicolás, Trottmann, Marie-Madeleine, Vignoles, Rory, Foucault, Louis, Verrier, Charlotte, Massera, Céline, Raineteau, Olivier, Conzelmann, Karl-Klaus, Rival-Gervier, Sylvie, Depaulis, Antoine, Berninger, Benedikt, Heinrich, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657801/
https://www.ncbi.nlm.nih.gov/pubmed/34592167
http://dx.doi.org/10.1016/j.stem.2021.09.002

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