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The Immunotherapy for Colorectal Cancer, Lung Cancer and Pancreatic Cancer

Immunotherapy is a novel anti-cancer method which employs a different mechanism to conventional treatment. It has become a significant strategy because it provides a better or an alternative option for cancer patients. Recently, immunotherapy has been increasingly approved for the treatment of cance...

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Detalles Bibliográficos
Autores principales: Chen, Shiu-Jau, Wang, Shao-Cheng, Chen, Yuan-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657810/
https://www.ncbi.nlm.nih.gov/pubmed/34884642
http://dx.doi.org/10.3390/ijms222312836
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author Chen, Shiu-Jau
Wang, Shao-Cheng
Chen, Yuan-Chuan
author_facet Chen, Shiu-Jau
Wang, Shao-Cheng
Chen, Yuan-Chuan
author_sort Chen, Shiu-Jau
collection PubMed
description Immunotherapy is a novel anti-cancer method which employs a different mechanism to conventional treatment. It has become a significant strategy because it provides a better or an alternative option for cancer patients. Recently, immunotherapy has been increasingly approved for the treatment of cancer; however, it has various limitations; for instance, it is only suitable for specific patients, the response rate is still low in most cases, etc. Colorectal cancer, lung cancer and pancreatic cancer are known as three major death-causing cancers in most countries. In this review, we discuss immunotherapeutic treatment for these three cancers, and consider the option, prospects and limitations of immunotherapy. The development of immunotherapy should focus on the discovery of biomarkers to screen suitable patients, new targets on tumors, neoadjuvant immunotherapy and the combination of immunotherapy with conventional therapeutic methods. We can expect that immunotherapy potentially will develop as one of the best therapies for patients with advanced cancer or poor responses to traditional methods.
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spelling pubmed-86578102021-12-10 The Immunotherapy for Colorectal Cancer, Lung Cancer and Pancreatic Cancer Chen, Shiu-Jau Wang, Shao-Cheng Chen, Yuan-Chuan Int J Mol Sci Review Immunotherapy is a novel anti-cancer method which employs a different mechanism to conventional treatment. It has become a significant strategy because it provides a better or an alternative option for cancer patients. Recently, immunotherapy has been increasingly approved for the treatment of cancer; however, it has various limitations; for instance, it is only suitable for specific patients, the response rate is still low in most cases, etc. Colorectal cancer, lung cancer and pancreatic cancer are known as three major death-causing cancers in most countries. In this review, we discuss immunotherapeutic treatment for these three cancers, and consider the option, prospects and limitations of immunotherapy. The development of immunotherapy should focus on the discovery of biomarkers to screen suitable patients, new targets on tumors, neoadjuvant immunotherapy and the combination of immunotherapy with conventional therapeutic methods. We can expect that immunotherapy potentially will develop as one of the best therapies for patients with advanced cancer or poor responses to traditional methods. MDPI 2021-11-27 /pmc/articles/PMC8657810/ /pubmed/34884642 http://dx.doi.org/10.3390/ijms222312836 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Shiu-Jau
Wang, Shao-Cheng
Chen, Yuan-Chuan
The Immunotherapy for Colorectal Cancer, Lung Cancer and Pancreatic Cancer
title The Immunotherapy for Colorectal Cancer, Lung Cancer and Pancreatic Cancer
title_full The Immunotherapy for Colorectal Cancer, Lung Cancer and Pancreatic Cancer
title_fullStr The Immunotherapy for Colorectal Cancer, Lung Cancer and Pancreatic Cancer
title_full_unstemmed The Immunotherapy for Colorectal Cancer, Lung Cancer and Pancreatic Cancer
title_short The Immunotherapy for Colorectal Cancer, Lung Cancer and Pancreatic Cancer
title_sort immunotherapy for colorectal cancer, lung cancer and pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657810/
https://www.ncbi.nlm.nih.gov/pubmed/34884642
http://dx.doi.org/10.3390/ijms222312836
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