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Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review
The purpose of this systematic review was to map out and summarize scientific evidence on dysregulated microRNAs (miRNAs) that can be possible biomarkers or therapeutic targets for cisplatin nephrotoxicity and have already been tested in humans, animals, or cells. In addition, an in silico analysis...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657822/ https://www.ncbi.nlm.nih.gov/pubmed/34884570 http://dx.doi.org/10.3390/ijms222312765 |
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author | de Godoy Torso, Nadine Pereira, João Kleber Novais Visacri, Marília Berlofa Vasconcelos, Pedro Eduardo Nascimento Silva Loren, Pía Saavedra, Kathleen Saavedra, Nicolás Salazar, Luis A. Moriel, Patricia |
author_facet | de Godoy Torso, Nadine Pereira, João Kleber Novais Visacri, Marília Berlofa Vasconcelos, Pedro Eduardo Nascimento Silva Loren, Pía Saavedra, Kathleen Saavedra, Nicolás Salazar, Luis A. Moriel, Patricia |
author_sort | de Godoy Torso, Nadine |
collection | PubMed |
description | The purpose of this systematic review was to map out and summarize scientific evidence on dysregulated microRNAs (miRNAs) that can be possible biomarkers or therapeutic targets for cisplatin nephrotoxicity and have already been tested in humans, animals, or cells. In addition, an in silico analysis of the two miRNAs found to be dysregulated in the majority of studies was performed. A literature search was performed using eight databases for studies published up to 4 July 2021. Two independent reviewers selected the studies and extracted the data; disagreements were resolved by a third and fourth reviewers. A total of 1002 records were identified, of which 30 met the eligibility criteria. All studies were published in English and reported between 2010 and 2021. The main findings were as follows: (a) miR-34a and miR-21 were the main miRNAs identified by the studies as possible biomarkers and therapeutic targets of cisplatin nephrotoxicity; (b) the in silico analysis revealed 124 and 131 different strongly validated targets for miR-34a and miR-21, respectively; and (c) studies in humans remain scarce. |
format | Online Article Text |
id | pubmed-8657822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86578222021-12-10 Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review de Godoy Torso, Nadine Pereira, João Kleber Novais Visacri, Marília Berlofa Vasconcelos, Pedro Eduardo Nascimento Silva Loren, Pía Saavedra, Kathleen Saavedra, Nicolás Salazar, Luis A. Moriel, Patricia Int J Mol Sci Review The purpose of this systematic review was to map out and summarize scientific evidence on dysregulated microRNAs (miRNAs) that can be possible biomarkers or therapeutic targets for cisplatin nephrotoxicity and have already been tested in humans, animals, or cells. In addition, an in silico analysis of the two miRNAs found to be dysregulated in the majority of studies was performed. A literature search was performed using eight databases for studies published up to 4 July 2021. Two independent reviewers selected the studies and extracted the data; disagreements were resolved by a third and fourth reviewers. A total of 1002 records were identified, of which 30 met the eligibility criteria. All studies were published in English and reported between 2010 and 2021. The main findings were as follows: (a) miR-34a and miR-21 were the main miRNAs identified by the studies as possible biomarkers and therapeutic targets of cisplatin nephrotoxicity; (b) the in silico analysis revealed 124 and 131 different strongly validated targets for miR-34a and miR-21, respectively; and (c) studies in humans remain scarce. MDPI 2021-11-25 /pmc/articles/PMC8657822/ /pubmed/34884570 http://dx.doi.org/10.3390/ijms222312765 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review de Godoy Torso, Nadine Pereira, João Kleber Novais Visacri, Marília Berlofa Vasconcelos, Pedro Eduardo Nascimento Silva Loren, Pía Saavedra, Kathleen Saavedra, Nicolás Salazar, Luis A. Moriel, Patricia Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review |
title | Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review |
title_full | Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review |
title_fullStr | Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review |
title_full_unstemmed | Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review |
title_short | Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review |
title_sort | dysregulated micrornas as biomarkers or therapeutic targets in cisplatin-induced nephrotoxicity: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657822/ https://www.ncbi.nlm.nih.gov/pubmed/34884570 http://dx.doi.org/10.3390/ijms222312765 |
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