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The Expression Pattern of Genes Related to Melanogenesis and Endogenous Opioids in Psoriasis

The melanocortin system is a major regulator of stress responses in the skin and is responsible for the induction of melanin synthesis through activation of melanogenesis enzymes. The expression of both melanocortin system genes and melanogenesis enzyme genes is altered in psoriasis, and the focus h...

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Autores principales: Loite, Ulvi, Raam, Liisi, Reimann, Ene, Reemann, Paula, Prans, Ele, Traks, Tanel, Vasar, Eero, Silm, Helgi, Kingo, Külli, Kõks, Sulev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657874/
https://www.ncbi.nlm.nih.gov/pubmed/34884858
http://dx.doi.org/10.3390/ijms222313056
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author Loite, Ulvi
Raam, Liisi
Reimann, Ene
Reemann, Paula
Prans, Ele
Traks, Tanel
Vasar, Eero
Silm, Helgi
Kingo, Külli
Kõks, Sulev
author_facet Loite, Ulvi
Raam, Liisi
Reimann, Ene
Reemann, Paula
Prans, Ele
Traks, Tanel
Vasar, Eero
Silm, Helgi
Kingo, Külli
Kõks, Sulev
author_sort Loite, Ulvi
collection PubMed
description The melanocortin system is a major regulator of stress responses in the skin and is responsible for the induction of melanin synthesis through activation of melanogenesis enzymes. The expression of both melanocortin system genes and melanogenesis enzyme genes is altered in psoriasis, and the focus here was on twelve genes related to the signal transduction between them. Additionally, five endogenous opioid system genes that are involved in cutaneous inflammation were examined. Quantitative real-time-PCR was utilized to measure mRNA expression in punch biopsies from lesional and non-lesional skin of psoriasis patients and from the skin of healthy control subjects. Most of the genes related to melanogenesis were down-regulated in patients (CREB1, MITF, LEF1, USF1, MAPK14, ICAM1, PIK3CB, RPS6KB1, KIT, and ATRN). Conversely, an up-regulation occurred in the case of opioids (PENK, PDYN, and PNOC). The suppression of genes related to melanogenesis is in agreement with the reported reduction in pigmentation signaling in psoriatic skin and potentially results from the pro-inflammatory environment. The increase in endogenous opioids can be associated with their involvement in inflammatory dysregulation in psoriasis.
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spelling pubmed-86578742021-12-10 The Expression Pattern of Genes Related to Melanogenesis and Endogenous Opioids in Psoriasis Loite, Ulvi Raam, Liisi Reimann, Ene Reemann, Paula Prans, Ele Traks, Tanel Vasar, Eero Silm, Helgi Kingo, Külli Kõks, Sulev Int J Mol Sci Article The melanocortin system is a major regulator of stress responses in the skin and is responsible for the induction of melanin synthesis through activation of melanogenesis enzymes. The expression of both melanocortin system genes and melanogenesis enzyme genes is altered in psoriasis, and the focus here was on twelve genes related to the signal transduction between them. Additionally, five endogenous opioid system genes that are involved in cutaneous inflammation were examined. Quantitative real-time-PCR was utilized to measure mRNA expression in punch biopsies from lesional and non-lesional skin of psoriasis patients and from the skin of healthy control subjects. Most of the genes related to melanogenesis were down-regulated in patients (CREB1, MITF, LEF1, USF1, MAPK14, ICAM1, PIK3CB, RPS6KB1, KIT, and ATRN). Conversely, an up-regulation occurred in the case of opioids (PENK, PDYN, and PNOC). The suppression of genes related to melanogenesis is in agreement with the reported reduction in pigmentation signaling in psoriatic skin and potentially results from the pro-inflammatory environment. The increase in endogenous opioids can be associated with their involvement in inflammatory dysregulation in psoriasis. MDPI 2021-12-02 /pmc/articles/PMC8657874/ /pubmed/34884858 http://dx.doi.org/10.3390/ijms222313056 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Loite, Ulvi
Raam, Liisi
Reimann, Ene
Reemann, Paula
Prans, Ele
Traks, Tanel
Vasar, Eero
Silm, Helgi
Kingo, Külli
Kõks, Sulev
The Expression Pattern of Genes Related to Melanogenesis and Endogenous Opioids in Psoriasis
title The Expression Pattern of Genes Related to Melanogenesis and Endogenous Opioids in Psoriasis
title_full The Expression Pattern of Genes Related to Melanogenesis and Endogenous Opioids in Psoriasis
title_fullStr The Expression Pattern of Genes Related to Melanogenesis and Endogenous Opioids in Psoriasis
title_full_unstemmed The Expression Pattern of Genes Related to Melanogenesis and Endogenous Opioids in Psoriasis
title_short The Expression Pattern of Genes Related to Melanogenesis and Endogenous Opioids in Psoriasis
title_sort expression pattern of genes related to melanogenesis and endogenous opioids in psoriasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657874/
https://www.ncbi.nlm.nih.gov/pubmed/34884858
http://dx.doi.org/10.3390/ijms222313056
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