State-Targeting Stabilization of Adenosine A(2A) Receptor by Fusing a Custom-Made De Novo Designed α-Helical Protein

G-protein coupled receptors (GPCRs) are known for their low stability and large conformational changes upon transitions between multiple states. A widely used method for stabilizing these receptors is to make chimeric receptors by fusing soluble proteins (i.e., fusion partner proteins) into the intr...

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Detalles Bibliográficos
Autores principales: Mitsumoto, Masaya, Sugaya, Kanna, Kazama, Kazuki, Nakano, Ryosuke, Kosugi, Takahiro, Murata, Takeshi, Koga, Nobuyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657880/
https://www.ncbi.nlm.nih.gov/pubmed/34884716
http://dx.doi.org/10.3390/ijms222312906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657880/
https://www.ncbi.nlm.nih.gov/pubmed/34884716
http://dx.doi.org/10.3390/ijms222312906

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