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State-Targeting Stabilization of Adenosine A(2A) Receptor by Fusing a Custom-Made De Novo Designed α-Helical Protein
G-protein coupled receptors (GPCRs) are known for their low stability and large conformational changes upon transitions between multiple states. A widely used method for stabilizing these receptors is to make chimeric receptors by fusing soluble proteins (i.e., fusion partner proteins) into the intr...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657880/ https://www.ncbi.nlm.nih.gov/pubmed/34884716 http://dx.doi.org/10.3390/ijms222312906 |