Zfhx3 Transcription Factor Represses the Expression of SCN5A Gene and Decreases Sodium Current Density (I(Na))

The ZFHX3 and SCN5A genes encode the zinc finger homeobox 3 (Zfhx3) transcription factor (TF) and the human cardiac Na(+) channel (Nav1.5), respectively. The effects of Zfhx3 on the expression of the Nav1.5 channel, and in cardiac excitability, are currently unknown. Additionally, we identified thre...

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Detalles Bibliográficos
Autores principales: Rubio-Alarcón, Marcos, Cámara-Checa, Anabel, Dago, María, Crespo-García, Teresa, Nieto-Marín, Paloma, Marín, María, Merino, José Luis, Toquero, Jorge, Salguero-Bodes, Rafael, Tamargo, Juan, Cebrián, Jorge, Delpón, Eva, Caballero, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657907/
https://www.ncbi.nlm.nih.gov/pubmed/34884836
http://dx.doi.org/10.3390/ijms222313031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657907/
https://www.ncbi.nlm.nih.gov/pubmed/34884836
http://dx.doi.org/10.3390/ijms222313031

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