Development of Minicircle Vectors Encoding COL7A1 Gene with Human Promoters for Non-Viral Gene Therapy for Recessive Dystrophic Epidermolysis Bullosa

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare autosomal inherited skin disorder caused by mutations in the COL7A1 gene that encodes type VII collagen (C7). The development of an efficient gene replacement strategy for RDEB is mainly hindered by the lack of vectors able to encapsulate a...

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Detalles Bibliográficos
Autores principales: Wang, Xianqing, Alshehri, Fatma, Manzanares, Darío, Li, Yinghao, He, Zhonglei, Qiu, Bei, Zeng, Ming, A, Sigen, Lara-Sáez, Irene, Wang, Wenxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657908/
https://www.ncbi.nlm.nih.gov/pubmed/34884578
http://dx.doi.org/10.3390/ijms222312774

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