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Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function

The process of phase separation allows for the establishment and formation of subcompartmentalized structures, thus enabling cells to perform simultaneous processes with precise organization and low energy requirements. Chemical modifications of proteins, RNA, and lipids alter the molecular environm...

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Detalles Bibliográficos
Autores principales: Guillen-Chable, Francisco, Bayona, Andrea, Rodríguez-Zapata, Luis Carlos, Castano, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657925/
https://www.ncbi.nlm.nih.gov/pubmed/34884901
http://dx.doi.org/10.3390/ijms222313095
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author Guillen-Chable, Francisco
Bayona, Andrea
Rodríguez-Zapata, Luis Carlos
Castano, Enrique
author_facet Guillen-Chable, Francisco
Bayona, Andrea
Rodríguez-Zapata, Luis Carlos
Castano, Enrique
author_sort Guillen-Chable, Francisco
collection PubMed
description The process of phase separation allows for the establishment and formation of subcompartmentalized structures, thus enabling cells to perform simultaneous processes with precise organization and low energy requirements. Chemical modifications of proteins, RNA, and lipids alter the molecular environment facilitating enzymatic reactions at higher concentrations in particular regions of the cell. In this review, we discuss the nucleolus as an example of the establishment, dynamics, and maintenance of a membraneless organelle with a high level of organization.
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spelling pubmed-86579252021-12-10 Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function Guillen-Chable, Francisco Bayona, Andrea Rodríguez-Zapata, Luis Carlos Castano, Enrique Int J Mol Sci Review The process of phase separation allows for the establishment and formation of subcompartmentalized structures, thus enabling cells to perform simultaneous processes with precise organization and low energy requirements. Chemical modifications of proteins, RNA, and lipids alter the molecular environment facilitating enzymatic reactions at higher concentrations in particular regions of the cell. In this review, we discuss the nucleolus as an example of the establishment, dynamics, and maintenance of a membraneless organelle with a high level of organization. MDPI 2021-12-03 /pmc/articles/PMC8657925/ /pubmed/34884901 http://dx.doi.org/10.3390/ijms222313095 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guillen-Chable, Francisco
Bayona, Andrea
Rodríguez-Zapata, Luis Carlos
Castano, Enrique
Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function
title Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function
title_full Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function
title_fullStr Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function
title_full_unstemmed Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function
title_short Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function
title_sort phase separation of intrinsically disordered nucleolar proteins relate to localization and function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657925/
https://www.ncbi.nlm.nih.gov/pubmed/34884901
http://dx.doi.org/10.3390/ijms222313095
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