A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis

Myasthenia gravis (MG) is an autoimmune condition related to autoantibodies against certain proteins in the postsynaptic membranes in the neuromuscular junction. This disorder has a multifactorial inheritance. The connection between environmental and genetic factors can be established by epigenetic...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghafouri-Fard, Soudeh, Azimi, Tahereh, Hussen, Bashdar Mahmud, Taheri, Mohammad, Jalili Khoshnoud, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657981/
https://www.ncbi.nlm.nih.gov/pubmed/34884767
http://dx.doi.org/10.3390/ijms222312964
_version_ 1784612625745707008
author Ghafouri-Fard, Soudeh
Azimi, Tahereh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Jalili Khoshnoud, Reza
author_facet Ghafouri-Fard, Soudeh
Azimi, Tahereh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Jalili Khoshnoud, Reza
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description Myasthenia gravis (MG) is an autoimmune condition related to autoantibodies against certain proteins in the postsynaptic membranes in the neuromuscular junction. This disorder has a multifactorial inheritance. The connection between environmental and genetic factors can be established by epigenetic factors, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). XLOC_003810, SNHG16, IFNG-AS1, and MALAT-1 are among the lncRNAs with a possible role in the pathoetiology of MG. Moreover, miR-150-5p, miR-155, miR-146a-5p, miR-20b, miR-21-5p, miR-126, let-7a-5p, and let-7f-5p are among miRNAs whose roles in the pathogenesis of MG has been assessed. In the current review, we summarize the impact of miRNAs and lncRNAs in the development or progression of MG.
format Online
Article
Text
id pubmed-8657981
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86579812021-12-10 A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis Ghafouri-Fard, Soudeh Azimi, Tahereh Hussen, Bashdar Mahmud Taheri, Mohammad Jalili Khoshnoud, Reza Int J Mol Sci Review Myasthenia gravis (MG) is an autoimmune condition related to autoantibodies against certain proteins in the postsynaptic membranes in the neuromuscular junction. This disorder has a multifactorial inheritance. The connection between environmental and genetic factors can be established by epigenetic factors, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). XLOC_003810, SNHG16, IFNG-AS1, and MALAT-1 are among the lncRNAs with a possible role in the pathoetiology of MG. Moreover, miR-150-5p, miR-155, miR-146a-5p, miR-20b, miR-21-5p, miR-126, let-7a-5p, and let-7f-5p are among miRNAs whose roles in the pathogenesis of MG has been assessed. In the current review, we summarize the impact of miRNAs and lncRNAs in the development or progression of MG. MDPI 2021-11-30 /pmc/articles/PMC8657981/ /pubmed/34884767 http://dx.doi.org/10.3390/ijms222312964 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ghafouri-Fard, Soudeh
Azimi, Tahereh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Jalili Khoshnoud, Reza
A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis
title A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis
title_full A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis
title_fullStr A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis
title_full_unstemmed A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis
title_short A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis
title_sort review on the role of non-coding rnas in the pathogenesis of myasthenia gravis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657981/
https://www.ncbi.nlm.nih.gov/pubmed/34884767
http://dx.doi.org/10.3390/ijms222312964
work_keys_str_mv AT ghafourifardsoudeh areviewontheroleofnoncodingrnasinthepathogenesisofmyastheniagravis
AT azimitahereh areviewontheroleofnoncodingrnasinthepathogenesisofmyastheniagravis
AT hussenbashdarmahmud areviewontheroleofnoncodingrnasinthepathogenesisofmyastheniagravis
AT taherimohammad areviewontheroleofnoncodingrnasinthepathogenesisofmyastheniagravis
AT jalilikhoshnoudreza areviewontheroleofnoncodingrnasinthepathogenesisofmyastheniagravis
AT ghafourifardsoudeh reviewontheroleofnoncodingrnasinthepathogenesisofmyastheniagravis
AT azimitahereh reviewontheroleofnoncodingrnasinthepathogenesisofmyastheniagravis
AT hussenbashdarmahmud reviewontheroleofnoncodingrnasinthepathogenesisofmyastheniagravis
AT taherimohammad reviewontheroleofnoncodingrnasinthepathogenesisofmyastheniagravis
AT jalilikhoshnoudreza reviewontheroleofnoncodingrnasinthepathogenesisofmyastheniagravis

Ejemplares similares