Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation

Acetyl-CoA carboxylase (ACC) is the first enzyme regulating de novo lipid synthesis via the carboxylation of acetyl-CoA into malonyl-CoA. The inhibition of its activity decreases lipogenesis and, in parallel, increases the acetyl-CoA content, which serves as a substrate for protein acetylation. Seve...

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Detalles Bibliográficos
Autores principales: Octave, Marie, Pirotton, Laurence, Ginion, Audrey, Robaux, Valentine, Lepropre, Sophie, Ambroise, Jérôme, Bouzin, Caroline, Guigas, Bruno, Giera, Martin, Foretz, Marc, Bertrand, Luc, Beauloye, Christophe, Horman, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658010/
https://www.ncbi.nlm.nih.gov/pubmed/34884932
http://dx.doi.org/10.3390/ijms222313129

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