PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc

Neuroblastoma is a severe childhood disease, accounting for ~10% of all infant cancers. The amplification of the MYCN gene, coding for the N-Myc transcription factor, is an essential marker correlated with tumor progression and poor prognosis. In neuroblastoma cells, the mitotic kinase Aurora-A (AUR...

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Detalles Bibliográficos
Autores principales: Boi, Dalila, Souvalidou, Fani, Capelli, Davide, Polverino, Federica, Marini, Grazia, Montanari, Roberta, Pochetti, Giorgio, Tramonti, Angela, Contestabile, Roberto, Trisciuoglio, Daniela, Carpinelli, Patrizia, Ascanelli, Camilla, Lindon, Catherine, De Leo, Alessandro, Saviano, Michele, Di Santo, Roberto, Costi, Roberta, Guarguaglini, Giulia, Paiardini, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658095/
https://www.ncbi.nlm.nih.gov/pubmed/34884931
http://dx.doi.org/10.3390/ijms222313122

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