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Portal Vein Thrombosis Is Associated with an Increased Incidence of Depression and Anxiety Disorders

Portal vein thrombosis (PVT) is a severe disease that adversely affects patients’ well-being. Data on the influence of PVT on the occurrence of depression or anxiety disorders are lacking. This study aimed to explore the impact of PVT on the incidence of depression and anxiety disorders diagnoses in...

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Autores principales: Gairing, Simon Johannes, Galle, Peter Robert, Schattenberg, Jörn M., Kostev, Karel, Labenz, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658138/
https://www.ncbi.nlm.nih.gov/pubmed/34884391
http://dx.doi.org/10.3390/jcm10235689
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author Gairing, Simon Johannes
Galle, Peter Robert
Schattenberg, Jörn M.
Kostev, Karel
Labenz, Christian
author_facet Gairing, Simon Johannes
Galle, Peter Robert
Schattenberg, Jörn M.
Kostev, Karel
Labenz, Christian
author_sort Gairing, Simon Johannes
collection PubMed
description Portal vein thrombosis (PVT) is a severe disease that adversely affects patients’ well-being. Data on the influence of PVT on the occurrence of depression or anxiety disorders are lacking. This study aimed to explore the impact of PVT on the incidence of depression and anxiety disorders diagnoses in a large German primary care cohort over a ten-year period. Patients with PVT were matched to non-PVT individuals by age, sex, yearly consultation frequency, index year and comorbidities in a 1:5 ratio. The primary outcome of the study was the incidence of depression and anxiety disorders. The relationship between PVT and both depression and anxiety disorders was investigated using Cox regression models. We compared 547 patients with PVT with 2735 matched individuals without PVT. Within 5 years of the index date, 17.4% of patients with PVT and 9.3% of non-PVT individuals were diagnosed with depression (p < 0.001). Anxiety disorders were diagnosed in 5.5% and 3.0% of patients with PVT and non-PVT individuals, respectively (p = 0.002). On regression analyses, PVT was positively associated with incident depression (HR 2.01, 95% CI 1.53–2.64, p < 0.001) as well as anxiety disorders (HR 2.16, 95% CI 1.35–3.46, p = 0.001). Regarding depression, this association remained significant in women as well as in men. There was no association between PVT and the incidence of anxiety disorders in women. In conclusion, PVT is associated with the development of depression and anxiety disorders. However, further prospective studies are needed to confirm our findings before definitive recommendations can be made.
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spelling pubmed-86581382021-12-10 Portal Vein Thrombosis Is Associated with an Increased Incidence of Depression and Anxiety Disorders Gairing, Simon Johannes Galle, Peter Robert Schattenberg, Jörn M. Kostev, Karel Labenz, Christian J Clin Med Article Portal vein thrombosis (PVT) is a severe disease that adversely affects patients’ well-being. Data on the influence of PVT on the occurrence of depression or anxiety disorders are lacking. This study aimed to explore the impact of PVT on the incidence of depression and anxiety disorders diagnoses in a large German primary care cohort over a ten-year period. Patients with PVT were matched to non-PVT individuals by age, sex, yearly consultation frequency, index year and comorbidities in a 1:5 ratio. The primary outcome of the study was the incidence of depression and anxiety disorders. The relationship between PVT and both depression and anxiety disorders was investigated using Cox regression models. We compared 547 patients with PVT with 2735 matched individuals without PVT. Within 5 years of the index date, 17.4% of patients with PVT and 9.3% of non-PVT individuals were diagnosed with depression (p < 0.001). Anxiety disorders were diagnosed in 5.5% and 3.0% of patients with PVT and non-PVT individuals, respectively (p = 0.002). On regression analyses, PVT was positively associated with incident depression (HR 2.01, 95% CI 1.53–2.64, p < 0.001) as well as anxiety disorders (HR 2.16, 95% CI 1.35–3.46, p = 0.001). Regarding depression, this association remained significant in women as well as in men. There was no association between PVT and the incidence of anxiety disorders in women. In conclusion, PVT is associated with the development of depression and anxiety disorders. However, further prospective studies are needed to confirm our findings before definitive recommendations can be made. MDPI 2021-12-02 /pmc/articles/PMC8658138/ /pubmed/34884391 http://dx.doi.org/10.3390/jcm10235689 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gairing, Simon Johannes
Galle, Peter Robert
Schattenberg, Jörn M.
Kostev, Karel
Labenz, Christian
Portal Vein Thrombosis Is Associated with an Increased Incidence of Depression and Anxiety Disorders
title Portal Vein Thrombosis Is Associated with an Increased Incidence of Depression and Anxiety Disorders
title_full Portal Vein Thrombosis Is Associated with an Increased Incidence of Depression and Anxiety Disorders
title_fullStr Portal Vein Thrombosis Is Associated with an Increased Incidence of Depression and Anxiety Disorders
title_full_unstemmed Portal Vein Thrombosis Is Associated with an Increased Incidence of Depression and Anxiety Disorders
title_short Portal Vein Thrombosis Is Associated with an Increased Incidence of Depression and Anxiety Disorders
title_sort portal vein thrombosis is associated with an increased incidence of depression and anxiety disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658138/
https://www.ncbi.nlm.nih.gov/pubmed/34884391
http://dx.doi.org/10.3390/jcm10235689
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