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Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues

The objective of the present study was to review the existing data on the association between Zn status and characteristics of gut microbiota in various organisms and the potential role of Zn-induced microbiota in modulating systemic effects. The existing data demonstrate a tight relationship betwee...

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Autores principales: Skalny, Anatoly V., Aschner, Michael, Lei, Xin Gen, Gritsenko, Viktor A., Santamaria, Abel, Alekseenko, Svetlana I., Prakash, Nagaraja Tejo, Chang, Jung-Su, Sizova, Elena A., Chao, Jane C. J., Aaseth, Jan, Tinkov, Alexey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658153/
https://www.ncbi.nlm.nih.gov/pubmed/34884881
http://dx.doi.org/10.3390/ijms222313074
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author Skalny, Anatoly V.
Aschner, Michael
Lei, Xin Gen
Gritsenko, Viktor A.
Santamaria, Abel
Alekseenko, Svetlana I.
Prakash, Nagaraja Tejo
Chang, Jung-Su
Sizova, Elena A.
Chao, Jane C. J.
Aaseth, Jan
Tinkov, Alexey A.
author_facet Skalny, Anatoly V.
Aschner, Michael
Lei, Xin Gen
Gritsenko, Viktor A.
Santamaria, Abel
Alekseenko, Svetlana I.
Prakash, Nagaraja Tejo
Chang, Jung-Su
Sizova, Elena A.
Chao, Jane C. J.
Aaseth, Jan
Tinkov, Alexey A.
author_sort Skalny, Anatoly V.
collection PubMed
description The objective of the present study was to review the existing data on the association between Zn status and characteristics of gut microbiota in various organisms and the potential role of Zn-induced microbiota in modulating systemic effects. The existing data demonstrate a tight relationship between Zn metabolism and gut microbiota as demonstrated in Zn deficiency, supplementation, and toxicity studies. Generally, Zn was found to be a significant factor for gut bacteria biodiversity. The effects of physiological and nutritional Zn doses also result in improved gut wall integrity, thus contributing to reduced translocation of bacteria and gut microbiome metabolites into the systemic circulation. In contrast, Zn overexposure induced substantial alterations in gut microbiota. In parallel with intestinal effects, systemic effects of Zn-induced gut microbiota modulation may include systemic inflammation and acute pancreatitis, autism spectrum disorder and attention deficit hyperactivity disorder, as well as fetal alcohol syndrome and obesity. In view of both Zn and gut microbiota, as well as their interaction in the regulation of the physiological functions of the host organism, addressing these targets through the use of Zn-enriched probiotics may be considered an effective strategy for health management.
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spelling pubmed-86581532021-12-10 Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues Skalny, Anatoly V. Aschner, Michael Lei, Xin Gen Gritsenko, Viktor A. Santamaria, Abel Alekseenko, Svetlana I. Prakash, Nagaraja Tejo Chang, Jung-Su Sizova, Elena A. Chao, Jane C. J. Aaseth, Jan Tinkov, Alexey A. Int J Mol Sci Review The objective of the present study was to review the existing data on the association between Zn status and characteristics of gut microbiota in various organisms and the potential role of Zn-induced microbiota in modulating systemic effects. The existing data demonstrate a tight relationship between Zn metabolism and gut microbiota as demonstrated in Zn deficiency, supplementation, and toxicity studies. Generally, Zn was found to be a significant factor for gut bacteria biodiversity. The effects of physiological and nutritional Zn doses also result in improved gut wall integrity, thus contributing to reduced translocation of bacteria and gut microbiome metabolites into the systemic circulation. In contrast, Zn overexposure induced substantial alterations in gut microbiota. In parallel with intestinal effects, systemic effects of Zn-induced gut microbiota modulation may include systemic inflammation and acute pancreatitis, autism spectrum disorder and attention deficit hyperactivity disorder, as well as fetal alcohol syndrome and obesity. In view of both Zn and gut microbiota, as well as their interaction in the regulation of the physiological functions of the host organism, addressing these targets through the use of Zn-enriched probiotics may be considered an effective strategy for health management. MDPI 2021-12-03 /pmc/articles/PMC8658153/ /pubmed/34884881 http://dx.doi.org/10.3390/ijms222313074 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Skalny, Anatoly V.
Aschner, Michael
Lei, Xin Gen
Gritsenko, Viktor A.
Santamaria, Abel
Alekseenko, Svetlana I.
Prakash, Nagaraja Tejo
Chang, Jung-Su
Sizova, Elena A.
Chao, Jane C. J.
Aaseth, Jan
Tinkov, Alexey A.
Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues
title Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues
title_full Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues
title_fullStr Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues
title_full_unstemmed Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues
title_short Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues
title_sort gut microbiota as a mediator of essential and toxic effects of zinc in the intestines and other tissues
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658153/
https://www.ncbi.nlm.nih.gov/pubmed/34884881
http://dx.doi.org/10.3390/ijms222313074
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