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Longitudinal Analyses of the Reciprocity of Depression and Anxiety after Traumatic Brain Injury and Its Clinical Implications

Depression and anxiety are common following traumatic brain injury (TBI). Understanding their prevalence and interplay within the first year after TBI with differing severities may improve patients’ outcomes after TBI. Individuals with a clinical diagnosis of TBI recruited for the large European col...

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Autores principales: Wang, Biyao, Zeldovich, Marina, Rauen, Katrin, Wu, Yi-Jhen, Covic, Amra, Muller, Isabelle, Haagsma, Juanita A., Polinder, Suzanne, Menon, David, Asendorf, Thomas, Andelic, Nada, von Steinbuechel, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658198/
https://www.ncbi.nlm.nih.gov/pubmed/34884299
http://dx.doi.org/10.3390/jcm10235597
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author Wang, Biyao
Zeldovich, Marina
Rauen, Katrin
Wu, Yi-Jhen
Covic, Amra
Muller, Isabelle
Haagsma, Juanita A.
Polinder, Suzanne
Menon, David
Asendorf, Thomas
Andelic, Nada
von Steinbuechel, Nicole
author_facet Wang, Biyao
Zeldovich, Marina
Rauen, Katrin
Wu, Yi-Jhen
Covic, Amra
Muller, Isabelle
Haagsma, Juanita A.
Polinder, Suzanne
Menon, David
Asendorf, Thomas
Andelic, Nada
von Steinbuechel, Nicole
author_sort Wang, Biyao
collection PubMed
description Depression and anxiety are common following traumatic brain injury (TBI). Understanding their prevalence and interplay within the first year after TBI with differing severities may improve patients’ outcomes after TBI. Individuals with a clinical diagnosis of TBI recruited for the large European collaborative longitudinal study CENTER-TBI were screened for patient-reported major depression (MD) and generalized anxiety disorder (GAD) at three, six, and twelve months post-injury (N = 1683). Data were analyzed using autoregressive cross-lagged models. Sociodemographic, premorbid and injury-related factors were examined as risk factors. 14.1–15.5% of TBI patients reported moderate to severe MD at three to twelve months after TBI, 7.9–9.5% reported GAD. Depression and anxiety after TBI presented high within-domain persistency and cross-domain concurrent associations. MD at three months post-TBI had a significant impact on GAD at six months post-TBI, while both acted bidirectionally at six to twelve months post-TBI. Being more severely disabled, having experienced major extracranial injuries, an intensive care unit stay, and being female were risk factors for more severe MD and GAD. Major trauma and the level of consciousness after TBI were additionally associated with more severe MD, whereas being younger was related to more severe GAD. Individuals after TBI should be screened and treated for MD and GAD early on, as both psychiatric disturbances are highly persistent and bi-directional in their impact. More severely disabled patients are particularly vulnerable, and thus warrant timely screening and intensive follow-up treatment.
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spelling pubmed-86581982021-12-10 Longitudinal Analyses of the Reciprocity of Depression and Anxiety after Traumatic Brain Injury and Its Clinical Implications Wang, Biyao Zeldovich, Marina Rauen, Katrin Wu, Yi-Jhen Covic, Amra Muller, Isabelle Haagsma, Juanita A. Polinder, Suzanne Menon, David Asendorf, Thomas Andelic, Nada von Steinbuechel, Nicole J Clin Med Article Depression and anxiety are common following traumatic brain injury (TBI). Understanding their prevalence and interplay within the first year after TBI with differing severities may improve patients’ outcomes after TBI. Individuals with a clinical diagnosis of TBI recruited for the large European collaborative longitudinal study CENTER-TBI were screened for patient-reported major depression (MD) and generalized anxiety disorder (GAD) at three, six, and twelve months post-injury (N = 1683). Data were analyzed using autoregressive cross-lagged models. Sociodemographic, premorbid and injury-related factors were examined as risk factors. 14.1–15.5% of TBI patients reported moderate to severe MD at three to twelve months after TBI, 7.9–9.5% reported GAD. Depression and anxiety after TBI presented high within-domain persistency and cross-domain concurrent associations. MD at three months post-TBI had a significant impact on GAD at six months post-TBI, while both acted bidirectionally at six to twelve months post-TBI. Being more severely disabled, having experienced major extracranial injuries, an intensive care unit stay, and being female were risk factors for more severe MD and GAD. Major trauma and the level of consciousness after TBI were additionally associated with more severe MD, whereas being younger was related to more severe GAD. Individuals after TBI should be screened and treated for MD and GAD early on, as both psychiatric disturbances are highly persistent and bi-directional in their impact. More severely disabled patients are particularly vulnerable, and thus warrant timely screening and intensive follow-up treatment. MDPI 2021-11-28 /pmc/articles/PMC8658198/ /pubmed/34884299 http://dx.doi.org/10.3390/jcm10235597 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Biyao
Zeldovich, Marina
Rauen, Katrin
Wu, Yi-Jhen
Covic, Amra
Muller, Isabelle
Haagsma, Juanita A.
Polinder, Suzanne
Menon, David
Asendorf, Thomas
Andelic, Nada
von Steinbuechel, Nicole
Longitudinal Analyses of the Reciprocity of Depression and Anxiety after Traumatic Brain Injury and Its Clinical Implications
title Longitudinal Analyses of the Reciprocity of Depression and Anxiety after Traumatic Brain Injury and Its Clinical Implications
title_full Longitudinal Analyses of the Reciprocity of Depression and Anxiety after Traumatic Brain Injury and Its Clinical Implications
title_fullStr Longitudinal Analyses of the Reciprocity of Depression and Anxiety after Traumatic Brain Injury and Its Clinical Implications
title_full_unstemmed Longitudinal Analyses of the Reciprocity of Depression and Anxiety after Traumatic Brain Injury and Its Clinical Implications
title_short Longitudinal Analyses of the Reciprocity of Depression and Anxiety after Traumatic Brain Injury and Its Clinical Implications
title_sort longitudinal analyses of the reciprocity of depression and anxiety after traumatic brain injury and its clinical implications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658198/
https://www.ncbi.nlm.nih.gov/pubmed/34884299
http://dx.doi.org/10.3390/jcm10235597
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