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Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function

(1) Background: Highly sensitive cardiac troponin T (hs-cTnT) plays an essential role in the diagnosis of myocardial injury. The upper reference limit of the respective assay is generally applied, irrespective of age, renal function, or sex. We aimed to identify age-adjusted and sex-adjusted upper r...

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Autores principales: Gärtner, Christiane, Langhammer, Romy, Schmidt, Maria, Federbusch, Martin, Wirkner, Kerstin, Löffler, Markus, Isermann, Berend, Laufs, Ulrich, Wachter, Rolf, Kaiser, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658212/
https://www.ncbi.nlm.nih.gov/pubmed/34884210
http://dx.doi.org/10.3390/jcm10235508
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author Gärtner, Christiane
Langhammer, Romy
Schmidt, Maria
Federbusch, Martin
Wirkner, Kerstin
Löffler, Markus
Isermann, Berend
Laufs, Ulrich
Wachter, Rolf
Kaiser, Thorsten
author_facet Gärtner, Christiane
Langhammer, Romy
Schmidt, Maria
Federbusch, Martin
Wirkner, Kerstin
Löffler, Markus
Isermann, Berend
Laufs, Ulrich
Wachter, Rolf
Kaiser, Thorsten
author_sort Gärtner, Christiane
collection PubMed
description (1) Background: Highly sensitive cardiac troponin T (hs-cTnT) plays an essential role in the diagnosis of myocardial injury. The upper reference limit of the respective assay is generally applied, irrespective of age, renal function, or sex. We aimed to identify age-adjusted and sex-adjusted upper reference limits in relation to renal function in a large population-based cohort without cardiac diseases. (2) Methods: We included 5428 subjects of the population-based LIFE-Adult cohort, free of diagnosed cardiac diseases. Sex-adjusted and age-adjusted 99th percentiles for hs-cTnT in subjects with preserved renal function were obtained. (3) Results: The hs-cTnT values were higher in men of all age groups. In both sexes, an increasing age positively correlated with higher hs-cTnT values. Hs-cTnT weakly correlated with serum creatinine. The three-dimensional analysis of age, creatinine, and hs-cTnT showed no relevant additional effect of creatinine on hs-cTnT. In men aged above 60 and women above 70, the calculated 99th percentiles clearly exceeded the commonly applied thresholds. (4) Conclusion: Age and sex have a major impact on the serum concentration of hs-cTnT, while renal function does not. We propose to consider age-adjusted and sex-adjusted reference values.
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spelling pubmed-86582122021-12-10 Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function Gärtner, Christiane Langhammer, Romy Schmidt, Maria Federbusch, Martin Wirkner, Kerstin Löffler, Markus Isermann, Berend Laufs, Ulrich Wachter, Rolf Kaiser, Thorsten J Clin Med Article (1) Background: Highly sensitive cardiac troponin T (hs-cTnT) plays an essential role in the diagnosis of myocardial injury. The upper reference limit of the respective assay is generally applied, irrespective of age, renal function, or sex. We aimed to identify age-adjusted and sex-adjusted upper reference limits in relation to renal function in a large population-based cohort without cardiac diseases. (2) Methods: We included 5428 subjects of the population-based LIFE-Adult cohort, free of diagnosed cardiac diseases. Sex-adjusted and age-adjusted 99th percentiles for hs-cTnT in subjects with preserved renal function were obtained. (3) Results: The hs-cTnT values were higher in men of all age groups. In both sexes, an increasing age positively correlated with higher hs-cTnT values. Hs-cTnT weakly correlated with serum creatinine. The three-dimensional analysis of age, creatinine, and hs-cTnT showed no relevant additional effect of creatinine on hs-cTnT. In men aged above 60 and women above 70, the calculated 99th percentiles clearly exceeded the commonly applied thresholds. (4) Conclusion: Age and sex have a major impact on the serum concentration of hs-cTnT, while renal function does not. We propose to consider age-adjusted and sex-adjusted reference values. MDPI 2021-11-25 /pmc/articles/PMC8658212/ /pubmed/34884210 http://dx.doi.org/10.3390/jcm10235508 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gärtner, Christiane
Langhammer, Romy
Schmidt, Maria
Federbusch, Martin
Wirkner, Kerstin
Löffler, Markus
Isermann, Berend
Laufs, Ulrich
Wachter, Rolf
Kaiser, Thorsten
Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function
title Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function
title_full Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function
title_fullStr Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function
title_full_unstemmed Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function
title_short Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function
title_sort revisited upper reference limits for highly sensitive cardiac troponin t in relation to age, sex, and renal function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658212/
https://www.ncbi.nlm.nih.gov/pubmed/34884210
http://dx.doi.org/10.3390/jcm10235508
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