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Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment

Preparations containing calcipotriol combined with betamethasone dipropionate (in the forms of ointment, gel, and foam) are available for the topical treatment of psoriasis. This review summarizes the differences in the efficacy and safety of these formulations, as well as the preferences of patient...

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Autores principales: Rudnicka, Lidia, Olszewska, Małgorzata, Goldust, Mohamad, Waśkiel-Burnat, Anna, Warszawik-Hendzel, Olga, Dorożyński, Przemysław, Turło, Jadwiga, Rakowska, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658256/
https://www.ncbi.nlm.nih.gov/pubmed/34884291
http://dx.doi.org/10.3390/jcm10235589
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author Rudnicka, Lidia
Olszewska, Małgorzata
Goldust, Mohamad
Waśkiel-Burnat, Anna
Warszawik-Hendzel, Olga
Dorożyński, Przemysław
Turło, Jadwiga
Rakowska, Adriana
author_facet Rudnicka, Lidia
Olszewska, Małgorzata
Goldust, Mohamad
Waśkiel-Burnat, Anna
Warszawik-Hendzel, Olga
Dorożyński, Przemysław
Turło, Jadwiga
Rakowska, Adriana
author_sort Rudnicka, Lidia
collection PubMed
description Preparations containing calcipotriol combined with betamethasone dipropionate (in the forms of ointment, gel, and foam) are available for the topical treatment of psoriasis. This review summarizes the differences in the efficacy and safety of these formulations, as well as the preferences of patients with various forms of psoriasis (plaque, scalp, and nail psoriasis). It has been documented that foams provide higher bioavailability, resulting in increased efficacy in plaque psoriasis compared to ointments and gels. Gels or foams are preferred by patients for their different practical qualities (e.g., gels for “easy application”, and foams for “immediate relief”). The available data indicate that ointments may be the most effective formulation in nail psoriasis, and gels are preferred by patients with scalp psoriasis because of their cosmetic features. Treatment with a foam formulation is associated with a lower number of medical appointments compared to treatment with an ointment and with a lower probability of developing indications for systemic treatment. The safety profiles of foams, ointments, and gels are comparable, with the most common adverse effect being pruritus at the application site (in 5.8% of the patients). A long-term proactive maintenance therapy markedly reduces the number of relapses and is likely to close the gap between topical and systemic treatment in psoriasis.
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spelling pubmed-86582562021-12-10 Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment Rudnicka, Lidia Olszewska, Małgorzata Goldust, Mohamad Waśkiel-Burnat, Anna Warszawik-Hendzel, Olga Dorożyński, Przemysław Turło, Jadwiga Rakowska, Adriana J Clin Med Review Preparations containing calcipotriol combined with betamethasone dipropionate (in the forms of ointment, gel, and foam) are available for the topical treatment of psoriasis. This review summarizes the differences in the efficacy and safety of these formulations, as well as the preferences of patients with various forms of psoriasis (plaque, scalp, and nail psoriasis). It has been documented that foams provide higher bioavailability, resulting in increased efficacy in plaque psoriasis compared to ointments and gels. Gels or foams are preferred by patients for their different practical qualities (e.g., gels for “easy application”, and foams for “immediate relief”). The available data indicate that ointments may be the most effective formulation in nail psoriasis, and gels are preferred by patients with scalp psoriasis because of their cosmetic features. Treatment with a foam formulation is associated with a lower number of medical appointments compared to treatment with an ointment and with a lower probability of developing indications for systemic treatment. The safety profiles of foams, ointments, and gels are comparable, with the most common adverse effect being pruritus at the application site (in 5.8% of the patients). A long-term proactive maintenance therapy markedly reduces the number of relapses and is likely to close the gap between topical and systemic treatment in psoriasis. MDPI 2021-11-28 /pmc/articles/PMC8658256/ /pubmed/34884291 http://dx.doi.org/10.3390/jcm10235589 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rudnicka, Lidia
Olszewska, Małgorzata
Goldust, Mohamad
Waśkiel-Burnat, Anna
Warszawik-Hendzel, Olga
Dorożyński, Przemysław
Turło, Jadwiga
Rakowska, Adriana
Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment
title Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment
title_full Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment
title_fullStr Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment
title_full_unstemmed Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment
title_short Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment
title_sort efficacy and safety of different formulations of calcipotriol/betamethasone dipropionate in psoriasis: gel, foam, and ointment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658256/
https://www.ncbi.nlm.nih.gov/pubmed/34884291
http://dx.doi.org/10.3390/jcm10235589
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