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Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France

Objectives: To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors. Methods: This observational retrospective study was conducted in six intensive...

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Autores principales: Volff, Maxime, Tonon, David, Bommel, Youri, Peres, Noémie, Lagier, David, Agard, Geoffray, Jacquier, Alexis, Bartoli, Axel, Carvelli, Julien, Max, Howard, Simeone, Pierre, Blasco, Valery, Pastene, Bruno, Loundou, Anderson, Boyer, Laurent, Leone, Marc, Velly, Lionel, Bourenne, Jeremy, Boussen, Salah, Bobot, Mickaël, Bruder, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658321/
https://www.ncbi.nlm.nih.gov/pubmed/34884353
http://dx.doi.org/10.3390/jcm10235650
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author Volff, Maxime
Tonon, David
Bommel, Youri
Peres, Noémie
Lagier, David
Agard, Geoffray
Jacquier, Alexis
Bartoli, Axel
Carvelli, Julien
Max, Howard
Simeone, Pierre
Blasco, Valery
Pastene, Bruno
Loundou, Anderson
Boyer, Laurent
Leone, Marc
Velly, Lionel
Bourenne, Jeremy
Boussen, Salah
Bobot, Mickaël
Bruder, Nicolas
author_facet Volff, Maxime
Tonon, David
Bommel, Youri
Peres, Noémie
Lagier, David
Agard, Geoffray
Jacquier, Alexis
Bartoli, Axel
Carvelli, Julien
Max, Howard
Simeone, Pierre
Blasco, Valery
Pastene, Bruno
Loundou, Anderson
Boyer, Laurent
Leone, Marc
Velly, Lionel
Bourenne, Jeremy
Boussen, Salah
Bobot, Mickaël
Bruder, Nicolas
author_sort Volff, Maxime
collection PubMed
description Objectives: To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors. Methods: This observational retrospective study was conducted in six intensive care units (ICUs) in three university hospitals in Marseille, France. Between 10 March and 10 May 2020, all adult patients admitted in ICU with laboratory-confirmed SARS-CoV-2 and respiratory failure were eligible for inclusion. The statistical analysis was focused on the mechanically ventilated patients. The primary outcome was the 90-day mortality after ICU admission. Results: Included in the study were 172 patients with COVID-19 related respiratory failure, 117 of whom (67%) received invasive mechanical ventilation. 90-day mortality of the invasively ventilated patients was 27.4%. Median duration of ventilation and median length of stay in ICU for these patients were 20 (9–33) days and 29 (17–46) days. Mortality increased with the severity of ARDS at ICU admission. After multivariable analysis was carried out, risk factors associated with 90-day mortality were age, elevated Charlson comorbidity index, chronic statins intake and occurrence of an arterial thrombosis. Conclusion: In this cohort, age and number of comorbidities were the main predictors of mortality in invasively ventilated patients. The only modifiable factor associated with mortality in multivariate analysis was arterial thrombosis.
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spelling pubmed-86583212021-12-10 Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France Volff, Maxime Tonon, David Bommel, Youri Peres, Noémie Lagier, David Agard, Geoffray Jacquier, Alexis Bartoli, Axel Carvelli, Julien Max, Howard Simeone, Pierre Blasco, Valery Pastene, Bruno Loundou, Anderson Boyer, Laurent Leone, Marc Velly, Lionel Bourenne, Jeremy Boussen, Salah Bobot, Mickaël Bruder, Nicolas J Clin Med Article Objectives: To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors. Methods: This observational retrospective study was conducted in six intensive care units (ICUs) in three university hospitals in Marseille, France. Between 10 March and 10 May 2020, all adult patients admitted in ICU with laboratory-confirmed SARS-CoV-2 and respiratory failure were eligible for inclusion. The statistical analysis was focused on the mechanically ventilated patients. The primary outcome was the 90-day mortality after ICU admission. Results: Included in the study were 172 patients with COVID-19 related respiratory failure, 117 of whom (67%) received invasive mechanical ventilation. 90-day mortality of the invasively ventilated patients was 27.4%. Median duration of ventilation and median length of stay in ICU for these patients were 20 (9–33) days and 29 (17–46) days. Mortality increased with the severity of ARDS at ICU admission. After multivariable analysis was carried out, risk factors associated with 90-day mortality were age, elevated Charlson comorbidity index, chronic statins intake and occurrence of an arterial thrombosis. Conclusion: In this cohort, age and number of comorbidities were the main predictors of mortality in invasively ventilated patients. The only modifiable factor associated with mortality in multivariate analysis was arterial thrombosis. MDPI 2021-11-30 /pmc/articles/PMC8658321/ /pubmed/34884353 http://dx.doi.org/10.3390/jcm10235650 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Volff, Maxime
Tonon, David
Bommel, Youri
Peres, Noémie
Lagier, David
Agard, Geoffray
Jacquier, Alexis
Bartoli, Axel
Carvelli, Julien
Max, Howard
Simeone, Pierre
Blasco, Valery
Pastene, Bruno
Loundou, Anderson
Boyer, Laurent
Leone, Marc
Velly, Lionel
Bourenne, Jeremy
Boussen, Salah
Bobot, Mickaël
Bruder, Nicolas
Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France
title Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France
title_full Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France
title_fullStr Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France
title_full_unstemmed Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France
title_short Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France
title_sort factors associated with 90-day mortality in invasively ventilated patients with covid-19 in marseille, france
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658321/
https://www.ncbi.nlm.nih.gov/pubmed/34884353
http://dx.doi.org/10.3390/jcm10235650
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