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Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France
Objectives: To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors. Methods: This observational retrospective study was conducted in six intensive...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658321/ https://www.ncbi.nlm.nih.gov/pubmed/34884353 http://dx.doi.org/10.3390/jcm10235650 |
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author | Volff, Maxime Tonon, David Bommel, Youri Peres, Noémie Lagier, David Agard, Geoffray Jacquier, Alexis Bartoli, Axel Carvelli, Julien Max, Howard Simeone, Pierre Blasco, Valery Pastene, Bruno Loundou, Anderson Boyer, Laurent Leone, Marc Velly, Lionel Bourenne, Jeremy Boussen, Salah Bobot, Mickaël Bruder, Nicolas |
author_facet | Volff, Maxime Tonon, David Bommel, Youri Peres, Noémie Lagier, David Agard, Geoffray Jacquier, Alexis Bartoli, Axel Carvelli, Julien Max, Howard Simeone, Pierre Blasco, Valery Pastene, Bruno Loundou, Anderson Boyer, Laurent Leone, Marc Velly, Lionel Bourenne, Jeremy Boussen, Salah Bobot, Mickaël Bruder, Nicolas |
author_sort | Volff, Maxime |
collection | PubMed |
description | Objectives: To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors. Methods: This observational retrospective study was conducted in six intensive care units (ICUs) in three university hospitals in Marseille, France. Between 10 March and 10 May 2020, all adult patients admitted in ICU with laboratory-confirmed SARS-CoV-2 and respiratory failure were eligible for inclusion. The statistical analysis was focused on the mechanically ventilated patients. The primary outcome was the 90-day mortality after ICU admission. Results: Included in the study were 172 patients with COVID-19 related respiratory failure, 117 of whom (67%) received invasive mechanical ventilation. 90-day mortality of the invasively ventilated patients was 27.4%. Median duration of ventilation and median length of stay in ICU for these patients were 20 (9–33) days and 29 (17–46) days. Mortality increased with the severity of ARDS at ICU admission. After multivariable analysis was carried out, risk factors associated with 90-day mortality were age, elevated Charlson comorbidity index, chronic statins intake and occurrence of an arterial thrombosis. Conclusion: In this cohort, age and number of comorbidities were the main predictors of mortality in invasively ventilated patients. The only modifiable factor associated with mortality in multivariate analysis was arterial thrombosis. |
format | Online Article Text |
id | pubmed-8658321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86583212021-12-10 Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France Volff, Maxime Tonon, David Bommel, Youri Peres, Noémie Lagier, David Agard, Geoffray Jacquier, Alexis Bartoli, Axel Carvelli, Julien Max, Howard Simeone, Pierre Blasco, Valery Pastene, Bruno Loundou, Anderson Boyer, Laurent Leone, Marc Velly, Lionel Bourenne, Jeremy Boussen, Salah Bobot, Mickaël Bruder, Nicolas J Clin Med Article Objectives: To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors. Methods: This observational retrospective study was conducted in six intensive care units (ICUs) in three university hospitals in Marseille, France. Between 10 March and 10 May 2020, all adult patients admitted in ICU with laboratory-confirmed SARS-CoV-2 and respiratory failure were eligible for inclusion. The statistical analysis was focused on the mechanically ventilated patients. The primary outcome was the 90-day mortality after ICU admission. Results: Included in the study were 172 patients with COVID-19 related respiratory failure, 117 of whom (67%) received invasive mechanical ventilation. 90-day mortality of the invasively ventilated patients was 27.4%. Median duration of ventilation and median length of stay in ICU for these patients were 20 (9–33) days and 29 (17–46) days. Mortality increased with the severity of ARDS at ICU admission. After multivariable analysis was carried out, risk factors associated with 90-day mortality were age, elevated Charlson comorbidity index, chronic statins intake and occurrence of an arterial thrombosis. Conclusion: In this cohort, age and number of comorbidities were the main predictors of mortality in invasively ventilated patients. The only modifiable factor associated with mortality in multivariate analysis was arterial thrombosis. MDPI 2021-11-30 /pmc/articles/PMC8658321/ /pubmed/34884353 http://dx.doi.org/10.3390/jcm10235650 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Volff, Maxime Tonon, David Bommel, Youri Peres, Noémie Lagier, David Agard, Geoffray Jacquier, Alexis Bartoli, Axel Carvelli, Julien Max, Howard Simeone, Pierre Blasco, Valery Pastene, Bruno Loundou, Anderson Boyer, Laurent Leone, Marc Velly, Lionel Bourenne, Jeremy Boussen, Salah Bobot, Mickaël Bruder, Nicolas Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France |
title | Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France |
title_full | Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France |
title_fullStr | Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France |
title_full_unstemmed | Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France |
title_short | Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France |
title_sort | factors associated with 90-day mortality in invasively ventilated patients with covid-19 in marseille, france |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658321/ https://www.ncbi.nlm.nih.gov/pubmed/34884353 http://dx.doi.org/10.3390/jcm10235650 |
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