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Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study

We aimed to investigate intracranial pressure (ICP) changes over time and the neurologic prognosis for out-of-hospital cardiac arrest (OHCA) survivors who received targeted temperature management (TTM). ICP was measured immediately after return of spontaneous circulation (ROSC) (day 1), then at 24 h...

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Autores principales: Song, Hogul, Kang, Changshin, Park, Jungsoo, You, Yeonho, In, Yongnam, Min, Jinhong, Jeong, Wonjoon, Cho, Yongchul, Ahn, Hongjoon, Kim, Dongil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658348/
https://www.ncbi.nlm.nih.gov/pubmed/34884400
http://dx.doi.org/10.3390/jcm10235697
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author Song, Hogul
Kang, Changshin
Park, Jungsoo
You, Yeonho
In, Yongnam
Min, Jinhong
Jeong, Wonjoon
Cho, Yongchul
Ahn, Hongjoon
Kim, Dongil
author_facet Song, Hogul
Kang, Changshin
Park, Jungsoo
You, Yeonho
In, Yongnam
Min, Jinhong
Jeong, Wonjoon
Cho, Yongchul
Ahn, Hongjoon
Kim, Dongil
author_sort Song, Hogul
collection PubMed
description We aimed to investigate intracranial pressure (ICP) changes over time and the neurologic prognosis for out-of-hospital cardiac arrest (OHCA) survivors who received targeted temperature management (TTM). ICP was measured immediately after return of spontaneous circulation (ROSC) (day 1), then at 24 h (day 2), 48 h (day 3), and 72 h (day 4), through connecting a lumbar drain catheter to a manometer or a LiquoGuard machine. Neurological outcomes were determined at 3 months after ROSC, and a poor neurological outcome was defined as Cerebral Performance Category 3–5. Of the 91 patients in this study (males, n = 67, 74%), 51 (56%) had poor neurological outcomes. ICP was significantly higher in the poor outcome group at each time point except day 4. ICP elevation was highest between days 2 and 3 in the good outcome group, and between days 1 and 2 in the poor outcome group. However, there was no difference in total ICP elevation between the poor and good outcome groups (3.0 vs. 3.1; p = 0.476). All OHCA survivors who had received TTM had elevated ICP, regardless of neurologic prognosis. However, the changing pattern of ICP levels differed depending on the neurological outcome.
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spelling pubmed-86583482021-12-10 Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study Song, Hogul Kang, Changshin Park, Jungsoo You, Yeonho In, Yongnam Min, Jinhong Jeong, Wonjoon Cho, Yongchul Ahn, Hongjoon Kim, Dongil J Clin Med Article We aimed to investigate intracranial pressure (ICP) changes over time and the neurologic prognosis for out-of-hospital cardiac arrest (OHCA) survivors who received targeted temperature management (TTM). ICP was measured immediately after return of spontaneous circulation (ROSC) (day 1), then at 24 h (day 2), 48 h (day 3), and 72 h (day 4), through connecting a lumbar drain catheter to a manometer or a LiquoGuard machine. Neurological outcomes were determined at 3 months after ROSC, and a poor neurological outcome was defined as Cerebral Performance Category 3–5. Of the 91 patients in this study (males, n = 67, 74%), 51 (56%) had poor neurological outcomes. ICP was significantly higher in the poor outcome group at each time point except day 4. ICP elevation was highest between days 2 and 3 in the good outcome group, and between days 1 and 2 in the poor outcome group. However, there was no difference in total ICP elevation between the poor and good outcome groups (3.0 vs. 3.1; p = 0.476). All OHCA survivors who had received TTM had elevated ICP, regardless of neurologic prognosis. However, the changing pattern of ICP levels differed depending on the neurological outcome. MDPI 2021-12-03 /pmc/articles/PMC8658348/ /pubmed/34884400 http://dx.doi.org/10.3390/jcm10235697 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Song, Hogul
Kang, Changshin
Park, Jungsoo
You, Yeonho
In, Yongnam
Min, Jinhong
Jeong, Wonjoon
Cho, Yongchul
Ahn, Hongjoon
Kim, Dongil
Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study
title Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study
title_full Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study
title_fullStr Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study
title_full_unstemmed Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study
title_short Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study
title_sort intracranial pressure patterns and neurological outcomes in out-of-hospital cardiac arrest survivors after targeted temperature management: a retrospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658348/
https://www.ncbi.nlm.nih.gov/pubmed/34884400
http://dx.doi.org/10.3390/jcm10235697
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