Cargando…
Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study
We aimed to investigate intracranial pressure (ICP) changes over time and the neurologic prognosis for out-of-hospital cardiac arrest (OHCA) survivors who received targeted temperature management (TTM). ICP was measured immediately after return of spontaneous circulation (ROSC) (day 1), then at 24 h...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658348/ https://www.ncbi.nlm.nih.gov/pubmed/34884400 http://dx.doi.org/10.3390/jcm10235697 |
_version_ | 1784612710792560640 |
---|---|
author | Song, Hogul Kang, Changshin Park, Jungsoo You, Yeonho In, Yongnam Min, Jinhong Jeong, Wonjoon Cho, Yongchul Ahn, Hongjoon Kim, Dongil |
author_facet | Song, Hogul Kang, Changshin Park, Jungsoo You, Yeonho In, Yongnam Min, Jinhong Jeong, Wonjoon Cho, Yongchul Ahn, Hongjoon Kim, Dongil |
author_sort | Song, Hogul |
collection | PubMed |
description | We aimed to investigate intracranial pressure (ICP) changes over time and the neurologic prognosis for out-of-hospital cardiac arrest (OHCA) survivors who received targeted temperature management (TTM). ICP was measured immediately after return of spontaneous circulation (ROSC) (day 1), then at 24 h (day 2), 48 h (day 3), and 72 h (day 4), through connecting a lumbar drain catheter to a manometer or a LiquoGuard machine. Neurological outcomes were determined at 3 months after ROSC, and a poor neurological outcome was defined as Cerebral Performance Category 3–5. Of the 91 patients in this study (males, n = 67, 74%), 51 (56%) had poor neurological outcomes. ICP was significantly higher in the poor outcome group at each time point except day 4. ICP elevation was highest between days 2 and 3 in the good outcome group, and between days 1 and 2 in the poor outcome group. However, there was no difference in total ICP elevation between the poor and good outcome groups (3.0 vs. 3.1; p = 0.476). All OHCA survivors who had received TTM had elevated ICP, regardless of neurologic prognosis. However, the changing pattern of ICP levels differed depending on the neurological outcome. |
format | Online Article Text |
id | pubmed-8658348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86583482021-12-10 Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study Song, Hogul Kang, Changshin Park, Jungsoo You, Yeonho In, Yongnam Min, Jinhong Jeong, Wonjoon Cho, Yongchul Ahn, Hongjoon Kim, Dongil J Clin Med Article We aimed to investigate intracranial pressure (ICP) changes over time and the neurologic prognosis for out-of-hospital cardiac arrest (OHCA) survivors who received targeted temperature management (TTM). ICP was measured immediately after return of spontaneous circulation (ROSC) (day 1), then at 24 h (day 2), 48 h (day 3), and 72 h (day 4), through connecting a lumbar drain catheter to a manometer or a LiquoGuard machine. Neurological outcomes were determined at 3 months after ROSC, and a poor neurological outcome was defined as Cerebral Performance Category 3–5. Of the 91 patients in this study (males, n = 67, 74%), 51 (56%) had poor neurological outcomes. ICP was significantly higher in the poor outcome group at each time point except day 4. ICP elevation was highest between days 2 and 3 in the good outcome group, and between days 1 and 2 in the poor outcome group. However, there was no difference in total ICP elevation between the poor and good outcome groups (3.0 vs. 3.1; p = 0.476). All OHCA survivors who had received TTM had elevated ICP, regardless of neurologic prognosis. However, the changing pattern of ICP levels differed depending on the neurological outcome. MDPI 2021-12-03 /pmc/articles/PMC8658348/ /pubmed/34884400 http://dx.doi.org/10.3390/jcm10235697 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Song, Hogul Kang, Changshin Park, Jungsoo You, Yeonho In, Yongnam Min, Jinhong Jeong, Wonjoon Cho, Yongchul Ahn, Hongjoon Kim, Dongil Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study |
title | Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study |
title_full | Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study |
title_fullStr | Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study |
title_full_unstemmed | Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study |
title_short | Intracranial Pressure Patterns and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Survivors after Targeted Temperature Management: A Retrospective Observational Study |
title_sort | intracranial pressure patterns and neurological outcomes in out-of-hospital cardiac arrest survivors after targeted temperature management: a retrospective observational study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658348/ https://www.ncbi.nlm.nih.gov/pubmed/34884400 http://dx.doi.org/10.3390/jcm10235697 |
work_keys_str_mv | AT songhogul intracranialpressurepatternsandneurologicaloutcomesinoutofhospitalcardiacarrestsurvivorsaftertargetedtemperaturemanagementaretrospectiveobservationalstudy AT kangchangshin intracranialpressurepatternsandneurologicaloutcomesinoutofhospitalcardiacarrestsurvivorsaftertargetedtemperaturemanagementaretrospectiveobservationalstudy AT parkjungsoo intracranialpressurepatternsandneurologicaloutcomesinoutofhospitalcardiacarrestsurvivorsaftertargetedtemperaturemanagementaretrospectiveobservationalstudy AT youyeonho intracranialpressurepatternsandneurologicaloutcomesinoutofhospitalcardiacarrestsurvivorsaftertargetedtemperaturemanagementaretrospectiveobservationalstudy AT inyongnam intracranialpressurepatternsandneurologicaloutcomesinoutofhospitalcardiacarrestsurvivorsaftertargetedtemperaturemanagementaretrospectiveobservationalstudy AT minjinhong intracranialpressurepatternsandneurologicaloutcomesinoutofhospitalcardiacarrestsurvivorsaftertargetedtemperaturemanagementaretrospectiveobservationalstudy AT jeongwonjoon intracranialpressurepatternsandneurologicaloutcomesinoutofhospitalcardiacarrestsurvivorsaftertargetedtemperaturemanagementaretrospectiveobservationalstudy AT choyongchul intracranialpressurepatternsandneurologicaloutcomesinoutofhospitalcardiacarrestsurvivorsaftertargetedtemperaturemanagementaretrospectiveobservationalstudy AT ahnhongjoon intracranialpressurepatternsandneurologicaloutcomesinoutofhospitalcardiacarrestsurvivorsaftertargetedtemperaturemanagementaretrospectiveobservationalstudy AT kimdongil intracranialpressurepatternsandneurologicaloutcomesinoutofhospitalcardiacarrestsurvivorsaftertargetedtemperaturemanagementaretrospectiveobservationalstudy |