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Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors
The identification of novel strategies to control Helicobacter pylori (Hp)-associated chronic inflammation is, at present, a considerable challenge. Here, we attempt to combat this issue by modulating the innate immune response, targeting formyl peptide receptors (FPRs), G-protein coupled receptors...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658387/ https://www.ncbi.nlm.nih.gov/pubmed/34884957 http://dx.doi.org/10.3390/ijms222313154 |
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author | Cuomo, Paola Medaglia, Chiara Allocca, Ivana Montone, Angela Michela Immacolata Guerra, Fabrizia Cabaro, Serena Mollo, Ernesto Eletto, Daniela Papaianni, Marina Capparelli, Rosanna |
author_facet | Cuomo, Paola Medaglia, Chiara Allocca, Ivana Montone, Angela Michela Immacolata Guerra, Fabrizia Cabaro, Serena Mollo, Ernesto Eletto, Daniela Papaianni, Marina Capparelli, Rosanna |
author_sort | Cuomo, Paola |
collection | PubMed |
description | The identification of novel strategies to control Helicobacter pylori (Hp)-associated chronic inflammation is, at present, a considerable challenge. Here, we attempt to combat this issue by modulating the innate immune response, targeting formyl peptide receptors (FPRs), G-protein coupled receptors that play key roles in both the regulation and the resolution of the innate inflammatory response. Specifically, we investigated, in vitro, whether Caulerpin—a bis-indole alkaloid isolated from algae of the genus Caulerpa—could act as a molecular antagonist scaffold of FPRs. We showed that Caulerpin significantly reduces the immune response against Hp culture filtrate, by reverting the FPR2-related signaling cascade and thus counteracting the inflammatory reaction triggered by Hp peptide Hp(2–20). Our study suggests Caulerpin to be a promising therapeutic or adjuvant agent for the attenuation of inflammation triggered by Hp infection, as well as its related adverse clinical outcomes. |
format | Online Article Text |
id | pubmed-8658387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86583872021-12-10 Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors Cuomo, Paola Medaglia, Chiara Allocca, Ivana Montone, Angela Michela Immacolata Guerra, Fabrizia Cabaro, Serena Mollo, Ernesto Eletto, Daniela Papaianni, Marina Capparelli, Rosanna Int J Mol Sci Article The identification of novel strategies to control Helicobacter pylori (Hp)-associated chronic inflammation is, at present, a considerable challenge. Here, we attempt to combat this issue by modulating the innate immune response, targeting formyl peptide receptors (FPRs), G-protein coupled receptors that play key roles in both the regulation and the resolution of the innate inflammatory response. Specifically, we investigated, in vitro, whether Caulerpin—a bis-indole alkaloid isolated from algae of the genus Caulerpa—could act as a molecular antagonist scaffold of FPRs. We showed that Caulerpin significantly reduces the immune response against Hp culture filtrate, by reverting the FPR2-related signaling cascade and thus counteracting the inflammatory reaction triggered by Hp peptide Hp(2–20). Our study suggests Caulerpin to be a promising therapeutic or adjuvant agent for the attenuation of inflammation triggered by Hp infection, as well as its related adverse clinical outcomes. MDPI 2021-12-05 /pmc/articles/PMC8658387/ /pubmed/34884957 http://dx.doi.org/10.3390/ijms222313154 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cuomo, Paola Medaglia, Chiara Allocca, Ivana Montone, Angela Michela Immacolata Guerra, Fabrizia Cabaro, Serena Mollo, Ernesto Eletto, Daniela Papaianni, Marina Capparelli, Rosanna Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors |
title | Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors |
title_full | Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors |
title_fullStr | Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors |
title_full_unstemmed | Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors |
title_short | Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors |
title_sort | caulerpin mitigates helicobacter pylori-induced inflammation via formyl peptide receptors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658387/ https://www.ncbi.nlm.nih.gov/pubmed/34884957 http://dx.doi.org/10.3390/ijms222313154 |
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