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Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors

The identification of novel strategies to control Helicobacter pylori (Hp)-associated chronic inflammation is, at present, a considerable challenge. Here, we attempt to combat this issue by modulating the innate immune response, targeting formyl peptide receptors (FPRs), G-protein coupled receptors...

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Autores principales: Cuomo, Paola, Medaglia, Chiara, Allocca, Ivana, Montone, Angela Michela Immacolata, Guerra, Fabrizia, Cabaro, Serena, Mollo, Ernesto, Eletto, Daniela, Papaianni, Marina, Capparelli, Rosanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658387/
https://www.ncbi.nlm.nih.gov/pubmed/34884957
http://dx.doi.org/10.3390/ijms222313154
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author Cuomo, Paola
Medaglia, Chiara
Allocca, Ivana
Montone, Angela Michela Immacolata
Guerra, Fabrizia
Cabaro, Serena
Mollo, Ernesto
Eletto, Daniela
Papaianni, Marina
Capparelli, Rosanna
author_facet Cuomo, Paola
Medaglia, Chiara
Allocca, Ivana
Montone, Angela Michela Immacolata
Guerra, Fabrizia
Cabaro, Serena
Mollo, Ernesto
Eletto, Daniela
Papaianni, Marina
Capparelli, Rosanna
author_sort Cuomo, Paola
collection PubMed
description The identification of novel strategies to control Helicobacter pylori (Hp)-associated chronic inflammation is, at present, a considerable challenge. Here, we attempt to combat this issue by modulating the innate immune response, targeting formyl peptide receptors (FPRs), G-protein coupled receptors that play key roles in both the regulation and the resolution of the innate inflammatory response. Specifically, we investigated, in vitro, whether Caulerpin—a bis-indole alkaloid isolated from algae of the genus Caulerpa—could act as a molecular antagonist scaffold of FPRs. We showed that Caulerpin significantly reduces the immune response against Hp culture filtrate, by reverting the FPR2-related signaling cascade and thus counteracting the inflammatory reaction triggered by Hp peptide Hp(2–20). Our study suggests Caulerpin to be a promising therapeutic or adjuvant agent for the attenuation of inflammation triggered by Hp infection, as well as its related adverse clinical outcomes.
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spelling pubmed-86583872021-12-10 Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors Cuomo, Paola Medaglia, Chiara Allocca, Ivana Montone, Angela Michela Immacolata Guerra, Fabrizia Cabaro, Serena Mollo, Ernesto Eletto, Daniela Papaianni, Marina Capparelli, Rosanna Int J Mol Sci Article The identification of novel strategies to control Helicobacter pylori (Hp)-associated chronic inflammation is, at present, a considerable challenge. Here, we attempt to combat this issue by modulating the innate immune response, targeting formyl peptide receptors (FPRs), G-protein coupled receptors that play key roles in both the regulation and the resolution of the innate inflammatory response. Specifically, we investigated, in vitro, whether Caulerpin—a bis-indole alkaloid isolated from algae of the genus Caulerpa—could act as a molecular antagonist scaffold of FPRs. We showed that Caulerpin significantly reduces the immune response against Hp culture filtrate, by reverting the FPR2-related signaling cascade and thus counteracting the inflammatory reaction triggered by Hp peptide Hp(2–20). Our study suggests Caulerpin to be a promising therapeutic or adjuvant agent for the attenuation of inflammation triggered by Hp infection, as well as its related adverse clinical outcomes. MDPI 2021-12-05 /pmc/articles/PMC8658387/ /pubmed/34884957 http://dx.doi.org/10.3390/ijms222313154 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cuomo, Paola
Medaglia, Chiara
Allocca, Ivana
Montone, Angela Michela Immacolata
Guerra, Fabrizia
Cabaro, Serena
Mollo, Ernesto
Eletto, Daniela
Papaianni, Marina
Capparelli, Rosanna
Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors
title Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors
title_full Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors
title_fullStr Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors
title_full_unstemmed Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors
title_short Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors
title_sort caulerpin mitigates helicobacter pylori-induced inflammation via formyl peptide receptors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658387/
https://www.ncbi.nlm.nih.gov/pubmed/34884957
http://dx.doi.org/10.3390/ijms222313154
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