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Overview of Drug Transporters in Human Placenta
The transport of drugs across the placenta is a point of great importance in pharmacotherapy during pregnancy. However, the knowledge of drug transport in pregnancy is mostly based on experimental clinical data, and the underlying biological mechanisms are not fully understood. In this review, we su...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658420/ https://www.ncbi.nlm.nih.gov/pubmed/34884954 http://dx.doi.org/10.3390/ijms222313149 |
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author | Yamashita, Michiko Markert, Udo R. |
author_facet | Yamashita, Michiko Markert, Udo R. |
author_sort | Yamashita, Michiko |
collection | PubMed |
description | The transport of drugs across the placenta is a point of great importance in pharmacotherapy during pregnancy. However, the knowledge of drug transport in pregnancy is mostly based on experimental clinical data, and the underlying biological mechanisms are not fully understood. In this review, we summarize the current knowledge of drug transporters in the human placenta. We only refer to human data since the placenta demonstrates great diversity among species. In addition, we describe the experimental models that have been used in human placental transport studies and discuss their availability. A better understanding of placental drug transporters will be beneficial for the health of pregnant women who need drug treatment and their fetuses. |
format | Online Article Text |
id | pubmed-8658420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86584202021-12-10 Overview of Drug Transporters in Human Placenta Yamashita, Michiko Markert, Udo R. Int J Mol Sci Review The transport of drugs across the placenta is a point of great importance in pharmacotherapy during pregnancy. However, the knowledge of drug transport in pregnancy is mostly based on experimental clinical data, and the underlying biological mechanisms are not fully understood. In this review, we summarize the current knowledge of drug transporters in the human placenta. We only refer to human data since the placenta demonstrates great diversity among species. In addition, we describe the experimental models that have been used in human placental transport studies and discuss their availability. A better understanding of placental drug transporters will be beneficial for the health of pregnant women who need drug treatment and their fetuses. MDPI 2021-12-05 /pmc/articles/PMC8658420/ /pubmed/34884954 http://dx.doi.org/10.3390/ijms222313149 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yamashita, Michiko Markert, Udo R. Overview of Drug Transporters in Human Placenta |
title | Overview of Drug Transporters in Human Placenta |
title_full | Overview of Drug Transporters in Human Placenta |
title_fullStr | Overview of Drug Transporters in Human Placenta |
title_full_unstemmed | Overview of Drug Transporters in Human Placenta |
title_short | Overview of Drug Transporters in Human Placenta |
title_sort | overview of drug transporters in human placenta |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658420/ https://www.ncbi.nlm.nih.gov/pubmed/34884954 http://dx.doi.org/10.3390/ijms222313149 |
work_keys_str_mv | AT yamashitamichiko overviewofdrugtransportersinhumanplacenta AT markertudor overviewofdrugtransportersinhumanplacenta |