Cargando…

Supraglottic Botulinum Toxin Improves Symptoms in Patients with Laryngeal Sensory Dysfunction Manifesting as Abnormal Throat Sensation and/or Chronic Refractory Cough

Laryngeal sensory dysfunction (LSD) encompasses disorders of the vagal sensory pathways. Common manifestations include chronic refractory cough (CRC) and abnormal throat sensation (ATS). This study examined clinical characteristics and treatment outcomes of LSD using a novel approach of laryngeal su...

Descripción completa

Detalles Bibliográficos
Autores principales: Novakovic, Daniel, Sheth, Meet, Stewart, Thomas, Sandham, Katrina, Madill, Catherine, Chacon, Antonia, Nguyen, Duy Duong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658444/
https://www.ncbi.nlm.nih.gov/pubmed/34884187
http://dx.doi.org/10.3390/jcm10235486
_version_ 1784612734083530752
author Novakovic, Daniel
Sheth, Meet
Stewart, Thomas
Sandham, Katrina
Madill, Catherine
Chacon, Antonia
Nguyen, Duy Duong
author_facet Novakovic, Daniel
Sheth, Meet
Stewart, Thomas
Sandham, Katrina
Madill, Catherine
Chacon, Antonia
Nguyen, Duy Duong
author_sort Novakovic, Daniel
collection PubMed
description Laryngeal sensory dysfunction (LSD) encompasses disorders of the vagal sensory pathways. Common manifestations include chronic refractory cough (CRC) and abnormal throat sensation (ATS). This study examined clinical characteristics and treatment outcomes of LSD using a novel approach of laryngeal supraglottic Onabotulinum toxin Type A injection (BTX). This was a retrospective review of clinical data and treatment outcomes of supraglottic BTX in patients with LSD. Between November 2019 and May 2021, 14 patients underwent 25 injection cycles of supraglottic BTX for treatment of symptoms related to LSD, including ATS and CRC. Primary outcome measures included the Newcastle Laryngeal Hypersensitivity Questionnaire (LHQ), Cough Severity Index (CSI), Reflux Symptom Index (RSI), and Voice Handicap Index-10 (VHI-10) at baseline and within three months of treatment. Pre- and post-treatment data were compared using a linear mixed model. After supraglottic BTX, LHQ scores improved by 2.6. RSI and CSI improved by 8.0 and 5.0, respectively. VHI-10 did not change as a result of treatment. Short-term response to SLN block was significantly associated with longer term response to BTX treatment. These findings suggest that LSD presents clinically as ATS and CRC along with other upper airway symptoms. Supraglottic BTX injection is a safe and effective technique in the treatment of symptoms of LSD.
format Online
Article
Text
id pubmed-8658444
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86584442021-12-10 Supraglottic Botulinum Toxin Improves Symptoms in Patients with Laryngeal Sensory Dysfunction Manifesting as Abnormal Throat Sensation and/or Chronic Refractory Cough Novakovic, Daniel Sheth, Meet Stewart, Thomas Sandham, Katrina Madill, Catherine Chacon, Antonia Nguyen, Duy Duong J Clin Med Article Laryngeal sensory dysfunction (LSD) encompasses disorders of the vagal sensory pathways. Common manifestations include chronic refractory cough (CRC) and abnormal throat sensation (ATS). This study examined clinical characteristics and treatment outcomes of LSD using a novel approach of laryngeal supraglottic Onabotulinum toxin Type A injection (BTX). This was a retrospective review of clinical data and treatment outcomes of supraglottic BTX in patients with LSD. Between November 2019 and May 2021, 14 patients underwent 25 injection cycles of supraglottic BTX for treatment of symptoms related to LSD, including ATS and CRC. Primary outcome measures included the Newcastle Laryngeal Hypersensitivity Questionnaire (LHQ), Cough Severity Index (CSI), Reflux Symptom Index (RSI), and Voice Handicap Index-10 (VHI-10) at baseline and within three months of treatment. Pre- and post-treatment data were compared using a linear mixed model. After supraglottic BTX, LHQ scores improved by 2.6. RSI and CSI improved by 8.0 and 5.0, respectively. VHI-10 did not change as a result of treatment. Short-term response to SLN block was significantly associated with longer term response to BTX treatment. These findings suggest that LSD presents clinically as ATS and CRC along with other upper airway symptoms. Supraglottic BTX injection is a safe and effective technique in the treatment of symptoms of LSD. MDPI 2021-11-23 /pmc/articles/PMC8658444/ /pubmed/34884187 http://dx.doi.org/10.3390/jcm10235486 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Novakovic, Daniel
Sheth, Meet
Stewart, Thomas
Sandham, Katrina
Madill, Catherine
Chacon, Antonia
Nguyen, Duy Duong
Supraglottic Botulinum Toxin Improves Symptoms in Patients with Laryngeal Sensory Dysfunction Manifesting as Abnormal Throat Sensation and/or Chronic Refractory Cough
title Supraglottic Botulinum Toxin Improves Symptoms in Patients with Laryngeal Sensory Dysfunction Manifesting as Abnormal Throat Sensation and/or Chronic Refractory Cough
title_full Supraglottic Botulinum Toxin Improves Symptoms in Patients with Laryngeal Sensory Dysfunction Manifesting as Abnormal Throat Sensation and/or Chronic Refractory Cough
title_fullStr Supraglottic Botulinum Toxin Improves Symptoms in Patients with Laryngeal Sensory Dysfunction Manifesting as Abnormal Throat Sensation and/or Chronic Refractory Cough
title_full_unstemmed Supraglottic Botulinum Toxin Improves Symptoms in Patients with Laryngeal Sensory Dysfunction Manifesting as Abnormal Throat Sensation and/or Chronic Refractory Cough
title_short Supraglottic Botulinum Toxin Improves Symptoms in Patients with Laryngeal Sensory Dysfunction Manifesting as Abnormal Throat Sensation and/or Chronic Refractory Cough
title_sort supraglottic botulinum toxin improves symptoms in patients with laryngeal sensory dysfunction manifesting as abnormal throat sensation and/or chronic refractory cough
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658444/
https://www.ncbi.nlm.nih.gov/pubmed/34884187
http://dx.doi.org/10.3390/jcm10235486
work_keys_str_mv AT novakovicdaniel supraglotticbotulinumtoxinimprovessymptomsinpatientswithlaryngealsensorydysfunctionmanifestingasabnormalthroatsensationandorchronicrefractorycough
AT shethmeet supraglotticbotulinumtoxinimprovessymptomsinpatientswithlaryngealsensorydysfunctionmanifestingasabnormalthroatsensationandorchronicrefractorycough
AT stewartthomas supraglotticbotulinumtoxinimprovessymptomsinpatientswithlaryngealsensorydysfunctionmanifestingasabnormalthroatsensationandorchronicrefractorycough
AT sandhamkatrina supraglotticbotulinumtoxinimprovessymptomsinpatientswithlaryngealsensorydysfunctionmanifestingasabnormalthroatsensationandorchronicrefractorycough
AT madillcatherine supraglotticbotulinumtoxinimprovessymptomsinpatientswithlaryngealsensorydysfunctionmanifestingasabnormalthroatsensationandorchronicrefractorycough
AT chaconantonia supraglotticbotulinumtoxinimprovessymptomsinpatientswithlaryngealsensorydysfunctionmanifestingasabnormalthroatsensationandorchronicrefractorycough
AT nguyenduyduong supraglotticbotulinumtoxinimprovessymptomsinpatientswithlaryngealsensorydysfunctionmanifestingasabnormalthroatsensationandorchronicrefractorycough