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PD-L1 Expression in Patients with Idiopathic Pulmonary Fibrosis

Background: Idiopathic pulmonary fibrosis (IPF) is the most common and severe form within the group of idiopathic interstitial pneumonias. It is characterized by repetitive alveolar injury in genetically susceptible individuals and abnormal wound healing, leading to dysregulated bronchiolar prolifer...

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Autores principales: Kronborg-White, Sissel, Madsen, Line Bille, Bendstrup, Elisabeth, Poletti, Venerino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658518/
https://www.ncbi.nlm.nih.gov/pubmed/34884264
http://dx.doi.org/10.3390/jcm10235562
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author Kronborg-White, Sissel
Madsen, Line Bille
Bendstrup, Elisabeth
Poletti, Venerino
author_facet Kronborg-White, Sissel
Madsen, Line Bille
Bendstrup, Elisabeth
Poletti, Venerino
author_sort Kronborg-White, Sissel
collection PubMed
description Background: Idiopathic pulmonary fibrosis (IPF) is the most common and severe form within the group of idiopathic interstitial pneumonias. It is characterized by repetitive alveolar injury in genetically susceptible individuals and abnormal wound healing, leading to dysregulated bronchiolar proliferation and excessive deposition of extracellular matrix, causing complete architectural distortion and fibrosis. Epithelial-to-mesenchymal transition is considered an important pathogenic event, a phenomenon also observed in various malignant neoplasms, in which tumor cells express programmed death-ligand one (PD-L1). The aim of this study was to assess the presence of PD-L1 in patients with IPF and other interstitial lung diseases (ILDs). Method: Patients with a clinically and radiologically suspected idiopathic interstitial pneumonia or other ILDs undergoing transbronchial cryobiopsy to confirm the diagnosis at the Department of Respiratory Diseases and Allergy, Aarhus University Hospital, were included in this prospective observational study. Cellular membrane PD-L1 expression in epithelial cells was determined using the DAKO PD-L1 IHC 22C3 PharmDx Kit. Results: Membrane-bound PD-L1 (mPD-L1) was found in twelve (28%) of the forty-three patients with IPF and in five (9%) of the fifty-five patients with other ILDs (p = 0.015). When adjusting for age, gender and smoking status, the odds ratio of having IPF when expressing mPD-L1 in alveolar and/or bronchiolar epithelial cells was 4.3 (CI: 1.3–14.3). Conclusion: Expression of mPD-L1 in epithelial cells in the lung parenchymal zones was detected in a consistent subgroup of patients with IPF compared to other interstitial pneumonias. Larger studies are needed to explore the role of mPD-L1 in patients with IPF.
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spelling pubmed-86585182021-12-10 PD-L1 Expression in Patients with Idiopathic Pulmonary Fibrosis Kronborg-White, Sissel Madsen, Line Bille Bendstrup, Elisabeth Poletti, Venerino J Clin Med Article Background: Idiopathic pulmonary fibrosis (IPF) is the most common and severe form within the group of idiopathic interstitial pneumonias. It is characterized by repetitive alveolar injury in genetically susceptible individuals and abnormal wound healing, leading to dysregulated bronchiolar proliferation and excessive deposition of extracellular matrix, causing complete architectural distortion and fibrosis. Epithelial-to-mesenchymal transition is considered an important pathogenic event, a phenomenon also observed in various malignant neoplasms, in which tumor cells express programmed death-ligand one (PD-L1). The aim of this study was to assess the presence of PD-L1 in patients with IPF and other interstitial lung diseases (ILDs). Method: Patients with a clinically and radiologically suspected idiopathic interstitial pneumonia or other ILDs undergoing transbronchial cryobiopsy to confirm the diagnosis at the Department of Respiratory Diseases and Allergy, Aarhus University Hospital, were included in this prospective observational study. Cellular membrane PD-L1 expression in epithelial cells was determined using the DAKO PD-L1 IHC 22C3 PharmDx Kit. Results: Membrane-bound PD-L1 (mPD-L1) was found in twelve (28%) of the forty-three patients with IPF and in five (9%) of the fifty-five patients with other ILDs (p = 0.015). When adjusting for age, gender and smoking status, the odds ratio of having IPF when expressing mPD-L1 in alveolar and/or bronchiolar epithelial cells was 4.3 (CI: 1.3–14.3). Conclusion: Expression of mPD-L1 in epithelial cells in the lung parenchymal zones was detected in a consistent subgroup of patients with IPF compared to other interstitial pneumonias. Larger studies are needed to explore the role of mPD-L1 in patients with IPF. MDPI 2021-11-26 /pmc/articles/PMC8658518/ /pubmed/34884264 http://dx.doi.org/10.3390/jcm10235562 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kronborg-White, Sissel
Madsen, Line Bille
Bendstrup, Elisabeth
Poletti, Venerino
PD-L1 Expression in Patients with Idiopathic Pulmonary Fibrosis
title PD-L1 Expression in Patients with Idiopathic Pulmonary Fibrosis
title_full PD-L1 Expression in Patients with Idiopathic Pulmonary Fibrosis
title_fullStr PD-L1 Expression in Patients with Idiopathic Pulmonary Fibrosis
title_full_unstemmed PD-L1 Expression in Patients with Idiopathic Pulmonary Fibrosis
title_short PD-L1 Expression in Patients with Idiopathic Pulmonary Fibrosis
title_sort pd-l1 expression in patients with idiopathic pulmonary fibrosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658518/
https://www.ncbi.nlm.nih.gov/pubmed/34884264
http://dx.doi.org/10.3390/jcm10235562
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