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Computational Fluid Dynamics Simulations of Mitral Paravalvular Leaks in Human Heart
In recent years, computational fluid dynamics (CFD) has been extensively used in biomedical research on heart diseases due to its non-invasiveness and relative ease of use in predicting flow patterns inside the cardiovascular system. In this study, a modeling approach involving CFD simulations was e...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658524/ https://www.ncbi.nlm.nih.gov/pubmed/34885504 http://dx.doi.org/10.3390/ma14237354 |
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author | Wojtas, Krzysztof Kozłowski, Michał Orciuch, Wojciech Makowski, Łukasz |
author_facet | Wojtas, Krzysztof Kozłowski, Michał Orciuch, Wojciech Makowski, Łukasz |
author_sort | Wojtas, Krzysztof |
collection | PubMed |
description | In recent years, computational fluid dynamics (CFD) has been extensively used in biomedical research on heart diseases due to its non-invasiveness and relative ease of use in predicting flow patterns inside the cardiovascular system. In this study, a modeling approach involving CFD simulations was employed to study hemodynamics inside the left ventricle (LV) of a human heart affected by a mitral paravalvular leak (PVL). A simplified LV geometry with four PVL variants that varied in shape and size was studied. Predicted blood flow parameters, mainly velocity and shear stress distributions, were used as indicators of how presence of PVLs correlates with risk and severity of hemolysis. The calculations performed in the study showed a high risk of hemolysis in all analyzed cases, with the maximum shear stress values considerably exceeding the safe level of 300 Pa. Results of our study indicated that there was no simple relationship between PVL geometry and the risk of hemolysis. Two factors that potentially played a role in hemolysis severity, namely erythrocyte exposure time and the volume of fluid in which shear stress exceeded a critical value, were not directly proportional to any of the characteristic geometrical parameters (shape, diameters, circumference, area, volume) of the PVL channel. Potential limitations of the proposed simplified approach of flow analysis are discussed, and possible modifications to increase the accuracy and plausibility of the results are presented. |
format | Online Article Text |
id | pubmed-8658524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86585242021-12-10 Computational Fluid Dynamics Simulations of Mitral Paravalvular Leaks in Human Heart Wojtas, Krzysztof Kozłowski, Michał Orciuch, Wojciech Makowski, Łukasz Materials (Basel) Article In recent years, computational fluid dynamics (CFD) has been extensively used in biomedical research on heart diseases due to its non-invasiveness and relative ease of use in predicting flow patterns inside the cardiovascular system. In this study, a modeling approach involving CFD simulations was employed to study hemodynamics inside the left ventricle (LV) of a human heart affected by a mitral paravalvular leak (PVL). A simplified LV geometry with four PVL variants that varied in shape and size was studied. Predicted blood flow parameters, mainly velocity and shear stress distributions, were used as indicators of how presence of PVLs correlates with risk and severity of hemolysis. The calculations performed in the study showed a high risk of hemolysis in all analyzed cases, with the maximum shear stress values considerably exceeding the safe level of 300 Pa. Results of our study indicated that there was no simple relationship between PVL geometry and the risk of hemolysis. Two factors that potentially played a role in hemolysis severity, namely erythrocyte exposure time and the volume of fluid in which shear stress exceeded a critical value, were not directly proportional to any of the characteristic geometrical parameters (shape, diameters, circumference, area, volume) of the PVL channel. Potential limitations of the proposed simplified approach of flow analysis are discussed, and possible modifications to increase the accuracy and plausibility of the results are presented. MDPI 2021-11-30 /pmc/articles/PMC8658524/ /pubmed/34885504 http://dx.doi.org/10.3390/ma14237354 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wojtas, Krzysztof Kozłowski, Michał Orciuch, Wojciech Makowski, Łukasz Computational Fluid Dynamics Simulations of Mitral Paravalvular Leaks in Human Heart |
title | Computational Fluid Dynamics Simulations of Mitral Paravalvular Leaks in Human Heart |
title_full | Computational Fluid Dynamics Simulations of Mitral Paravalvular Leaks in Human Heart |
title_fullStr | Computational Fluid Dynamics Simulations of Mitral Paravalvular Leaks in Human Heart |
title_full_unstemmed | Computational Fluid Dynamics Simulations of Mitral Paravalvular Leaks in Human Heart |
title_short | Computational Fluid Dynamics Simulations of Mitral Paravalvular Leaks in Human Heart |
title_sort | computational fluid dynamics simulations of mitral paravalvular leaks in human heart |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658524/ https://www.ncbi.nlm.nih.gov/pubmed/34885504 http://dx.doi.org/10.3390/ma14237354 |
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