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Heart Rate in Patients with SARS-CoV-2 Infection: Prevalence of High Values at Discharge and Relationship with Disease Severity

The most common arrhythmia associated with COronaVIrus-related Disease (COVID) infection is sinus tachycardia. It is not known if high Heart Rate (HR) in COVID is simply a marker of higher systemic response to sepsis or if its persistence could be related to a long-term autonomic dysfunction. The ai...

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Autores principales: Maloberti, Alessandro, Ughi, Nicola, Bernasconi, Davide Paolo, Rebora, Paola, Cartella, Iside, Grasso, Enzo, Lenoci, Deborah, Del Gaudio, Francesca, Algeri, Michela, Scarpellini, Sara, Perna, Enrico, Verde, Alessandro, Santolamazza, Caterina, Vicari, Francesco, Frigerio, Maria, Alberti, Antonia, Valsecchi, Maria Grazia, Rossetti, Claudio, Epis, Oscar Massimiliano, Giannattasio, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658577/
https://www.ncbi.nlm.nih.gov/pubmed/34884293
http://dx.doi.org/10.3390/jcm10235590
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author Maloberti, Alessandro
Ughi, Nicola
Bernasconi, Davide Paolo
Rebora, Paola
Cartella, Iside
Grasso, Enzo
Lenoci, Deborah
Del Gaudio, Francesca
Algeri, Michela
Scarpellini, Sara
Perna, Enrico
Verde, Alessandro
Santolamazza, Caterina
Vicari, Francesco
Frigerio, Maria
Alberti, Antonia
Valsecchi, Maria Grazia
Rossetti, Claudio
Epis, Oscar Massimiliano
Giannattasio, Cristina
author_facet Maloberti, Alessandro
Ughi, Nicola
Bernasconi, Davide Paolo
Rebora, Paola
Cartella, Iside
Grasso, Enzo
Lenoci, Deborah
Del Gaudio, Francesca
Algeri, Michela
Scarpellini, Sara
Perna, Enrico
Verde, Alessandro
Santolamazza, Caterina
Vicari, Francesco
Frigerio, Maria
Alberti, Antonia
Valsecchi, Maria Grazia
Rossetti, Claudio
Epis, Oscar Massimiliano
Giannattasio, Cristina
author_sort Maloberti, Alessandro
collection PubMed
description The most common arrhythmia associated with COronaVIrus-related Disease (COVID) infection is sinus tachycardia. It is not known if high Heart Rate (HR) in COVID is simply a marker of higher systemic response to sepsis or if its persistence could be related to a long-term autonomic dysfunction. The aim of our work is to assess the prevalence of elevated HR at discharge in patients hospitalized for COVID-19 and to evaluate the variables associated with it. We enrolled 697 cases of SARS-CoV2 infection admitted in our hospital after February 21 and discharged within 23 July 2020. We collected data on clinical history, vital signs, laboratory tests and pharmacological treatment. Severe disease was defined as the need for Intensive Care Unit (ICU) admission and/or mechanical ventilation. Median age was 59 years (first-third quartile 49, 74), and male was the prevalent gender (60.1%). 84.6% of the subjects showed a SARS-CoV-2 related pneumonia, and 13.2% resulted in a severe disease. Mean HR at admission was 90 ± 18 bpm with a mean decrease of 10 bpm to discharge. Only 5.5% of subjects presented HR > 100 bpm at discharge. Significant predictors of discharge HR at multiple linear model were admission HR (mean increase = β = 0.17 per bpm, 95% CI 0.11; 0.22, p < 0.001), haemoglobin (β = −0.64 per g/dL, 95% CI −1.19; −0.09, p = 0.023) and severe disease (β = 8.42, 95% CI 5.39; 11.45, p < 0.001). High HR at discharge in COVID-19 patients is not such a frequent consequence, but when it occurs it seems strongly related to a severe course of the disease.
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spelling pubmed-86585772021-12-10 Heart Rate in Patients with SARS-CoV-2 Infection: Prevalence of High Values at Discharge and Relationship with Disease Severity Maloberti, Alessandro Ughi, Nicola Bernasconi, Davide Paolo Rebora, Paola Cartella, Iside Grasso, Enzo Lenoci, Deborah Del Gaudio, Francesca Algeri, Michela Scarpellini, Sara Perna, Enrico Verde, Alessandro Santolamazza, Caterina Vicari, Francesco Frigerio, Maria Alberti, Antonia Valsecchi, Maria Grazia Rossetti, Claudio Epis, Oscar Massimiliano Giannattasio, Cristina J Clin Med Article The most common arrhythmia associated with COronaVIrus-related Disease (COVID) infection is sinus tachycardia. It is not known if high Heart Rate (HR) in COVID is simply a marker of higher systemic response to sepsis or if its persistence could be related to a long-term autonomic dysfunction. The aim of our work is to assess the prevalence of elevated HR at discharge in patients hospitalized for COVID-19 and to evaluate the variables associated with it. We enrolled 697 cases of SARS-CoV2 infection admitted in our hospital after February 21 and discharged within 23 July 2020. We collected data on clinical history, vital signs, laboratory tests and pharmacological treatment. Severe disease was defined as the need for Intensive Care Unit (ICU) admission and/or mechanical ventilation. Median age was 59 years (first-third quartile 49, 74), and male was the prevalent gender (60.1%). 84.6% of the subjects showed a SARS-CoV-2 related pneumonia, and 13.2% resulted in a severe disease. Mean HR at admission was 90 ± 18 bpm with a mean decrease of 10 bpm to discharge. Only 5.5% of subjects presented HR > 100 bpm at discharge. Significant predictors of discharge HR at multiple linear model were admission HR (mean increase = β = 0.17 per bpm, 95% CI 0.11; 0.22, p < 0.001), haemoglobin (β = −0.64 per g/dL, 95% CI −1.19; −0.09, p = 0.023) and severe disease (β = 8.42, 95% CI 5.39; 11.45, p < 0.001). High HR at discharge in COVID-19 patients is not such a frequent consequence, but when it occurs it seems strongly related to a severe course of the disease. MDPI 2021-11-28 /pmc/articles/PMC8658577/ /pubmed/34884293 http://dx.doi.org/10.3390/jcm10235590 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maloberti, Alessandro
Ughi, Nicola
Bernasconi, Davide Paolo
Rebora, Paola
Cartella, Iside
Grasso, Enzo
Lenoci, Deborah
Del Gaudio, Francesca
Algeri, Michela
Scarpellini, Sara
Perna, Enrico
Verde, Alessandro
Santolamazza, Caterina
Vicari, Francesco
Frigerio, Maria
Alberti, Antonia
Valsecchi, Maria Grazia
Rossetti, Claudio
Epis, Oscar Massimiliano
Giannattasio, Cristina
Heart Rate in Patients with SARS-CoV-2 Infection: Prevalence of High Values at Discharge and Relationship with Disease Severity
title Heart Rate in Patients with SARS-CoV-2 Infection: Prevalence of High Values at Discharge and Relationship with Disease Severity
title_full Heart Rate in Patients with SARS-CoV-2 Infection: Prevalence of High Values at Discharge and Relationship with Disease Severity
title_fullStr Heart Rate in Patients with SARS-CoV-2 Infection: Prevalence of High Values at Discharge and Relationship with Disease Severity
title_full_unstemmed Heart Rate in Patients with SARS-CoV-2 Infection: Prevalence of High Values at Discharge and Relationship with Disease Severity
title_short Heart Rate in Patients with SARS-CoV-2 Infection: Prevalence of High Values at Discharge and Relationship with Disease Severity
title_sort heart rate in patients with sars-cov-2 infection: prevalence of high values at discharge and relationship with disease severity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658577/
https://www.ncbi.nlm.nih.gov/pubmed/34884293
http://dx.doi.org/10.3390/jcm10235590
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