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Predictors of Lymph Node Metastasis in T1 Colorectal Cancer in Young Patients: Results from a National Cancer Registry

The objective of this study is to fill the knowledge gap by examining predictors of lymph node metastasis (LNM) in young patients, less than 45 years, using a national cancer registry. Methods: Patients diagnosed with T1 colorectal cancer were identified in the Surveillance, Epidemiology, and End Re...

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Autores principales: Ramai, Daryl, Singh, Jameel, Facciorusso, Antonio, Chandan, Saurabh, Dhindsa, Banreet, Dhaliwal, Amaninder, Galassi, Barbara, Tomasello, Gianluca, Ghidini, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658610/
https://www.ncbi.nlm.nih.gov/pubmed/34884212
http://dx.doi.org/10.3390/jcm10235511
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author Ramai, Daryl
Singh, Jameel
Facciorusso, Antonio
Chandan, Saurabh
Dhindsa, Banreet
Dhaliwal, Amaninder
Galassi, Barbara
Tomasello, Gianluca
Ghidini, Michele
author_facet Ramai, Daryl
Singh, Jameel
Facciorusso, Antonio
Chandan, Saurabh
Dhindsa, Banreet
Dhaliwal, Amaninder
Galassi, Barbara
Tomasello, Gianluca
Ghidini, Michele
author_sort Ramai, Daryl
collection PubMed
description The objective of this study is to fill the knowledge gap by examining predictors of lymph node metastasis (LNM) in young patients, less than 45 years, using a national cancer registry. Methods: Patients diagnosed with T1 colorectal cancer were identified in the Surveillance, Epidemiology, and End Results registry. In total, 692 patients with T1 colorectal cancer were identified. Most tumors occurred in white race (77.7%), between 40 and 44 years of age (49.4%), with grade III tumor differentiation (59.8%) and 1 to 1.9 cm size (32.2%), and were left-sided tumors (61.1%). The overall rate of LNM was 22.5% (n = 149). LNM was associated with tumor grade IV (undifferentiated) (odds ratio (OR) 2.94, CI: 1.06–8.12; p = 0.038), and increasing tumor size (1 cm–1.9 cm: OR 2.92, CI: 1.71–4.97, p < 0.001; 2.0 cm–2.9 cm: OR 2.00, CI: 1.05–3.77, p = 0.034; and ≥3.0 cm: OR 2.68, CI: 1.43–5.01, p = 0.002). Five-year cancer-specific survival for patients with LNM was 91% and for patients without LNM this was 98%. Adjusted cox proportion models showed that LNM was associated with a four times higher rate of mortality (hazard ratio (HR) 4.43, CI: 1.27–15.52, p = 0.020). In this population-based analysis of patients with T1 colorectal cancer, tumor size and grade were significant predictors of LNM.
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spelling pubmed-86586102021-12-10 Predictors of Lymph Node Metastasis in T1 Colorectal Cancer in Young Patients: Results from a National Cancer Registry Ramai, Daryl Singh, Jameel Facciorusso, Antonio Chandan, Saurabh Dhindsa, Banreet Dhaliwal, Amaninder Galassi, Barbara Tomasello, Gianluca Ghidini, Michele J Clin Med Article The objective of this study is to fill the knowledge gap by examining predictors of lymph node metastasis (LNM) in young patients, less than 45 years, using a national cancer registry. Methods: Patients diagnosed with T1 colorectal cancer were identified in the Surveillance, Epidemiology, and End Results registry. In total, 692 patients with T1 colorectal cancer were identified. Most tumors occurred in white race (77.7%), between 40 and 44 years of age (49.4%), with grade III tumor differentiation (59.8%) and 1 to 1.9 cm size (32.2%), and were left-sided tumors (61.1%). The overall rate of LNM was 22.5% (n = 149). LNM was associated with tumor grade IV (undifferentiated) (odds ratio (OR) 2.94, CI: 1.06–8.12; p = 0.038), and increasing tumor size (1 cm–1.9 cm: OR 2.92, CI: 1.71–4.97, p < 0.001; 2.0 cm–2.9 cm: OR 2.00, CI: 1.05–3.77, p = 0.034; and ≥3.0 cm: OR 2.68, CI: 1.43–5.01, p = 0.002). Five-year cancer-specific survival for patients with LNM was 91% and for patients without LNM this was 98%. Adjusted cox proportion models showed that LNM was associated with a four times higher rate of mortality (hazard ratio (HR) 4.43, CI: 1.27–15.52, p = 0.020). In this population-based analysis of patients with T1 colorectal cancer, tumor size and grade were significant predictors of LNM. MDPI 2021-11-25 /pmc/articles/PMC8658610/ /pubmed/34884212 http://dx.doi.org/10.3390/jcm10235511 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ramai, Daryl
Singh, Jameel
Facciorusso, Antonio
Chandan, Saurabh
Dhindsa, Banreet
Dhaliwal, Amaninder
Galassi, Barbara
Tomasello, Gianluca
Ghidini, Michele
Predictors of Lymph Node Metastasis in T1 Colorectal Cancer in Young Patients: Results from a National Cancer Registry
title Predictors of Lymph Node Metastasis in T1 Colorectal Cancer in Young Patients: Results from a National Cancer Registry
title_full Predictors of Lymph Node Metastasis in T1 Colorectal Cancer in Young Patients: Results from a National Cancer Registry
title_fullStr Predictors of Lymph Node Metastasis in T1 Colorectal Cancer in Young Patients: Results from a National Cancer Registry
title_full_unstemmed Predictors of Lymph Node Metastasis in T1 Colorectal Cancer in Young Patients: Results from a National Cancer Registry
title_short Predictors of Lymph Node Metastasis in T1 Colorectal Cancer in Young Patients: Results from a National Cancer Registry
title_sort predictors of lymph node metastasis in t1 colorectal cancer in young patients: results from a national cancer registry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658610/
https://www.ncbi.nlm.nih.gov/pubmed/34884212
http://dx.doi.org/10.3390/jcm10235511
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