Cargando…
Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin
DeoxyArbutin (dA) is a tyrosinase inhibitor that has effective skin-lightening activity and has no obvious cytotoxicity toward melanocytes. With the aim of directly evaluating the effects of microemulsions containing dA on cells, we developed oil-in-water (O/W) microemulsions with relatively lower c...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658635/ https://www.ncbi.nlm.nih.gov/pubmed/34884914 http://dx.doi.org/10.3390/ijms222313110 |
_version_ | 1784612776770011136 |
---|---|
author | Chang, Nai-Fang Tsai, Feng-Jie Zheng, Ya-Min Huang, Wei-Hsiang Lin, Chih-Chien |
author_facet | Chang, Nai-Fang Tsai, Feng-Jie Zheng, Ya-Min Huang, Wei-Hsiang Lin, Chih-Chien |
author_sort | Chang, Nai-Fang |
collection | PubMed |
description | DeoxyArbutin (dA) is a tyrosinase inhibitor that has effective skin-lightening activity and has no obvious cytotoxicity toward melanocytes. With the aim of directly evaluating the effects of microemulsions containing dA on cells, we developed oil-in-water (O/W) microemulsions with relatively lower cytotoxicities by using polysorbate-series surfactants. Measurement of the transparent properties and particle size analysis at different storage time periods revealed that the developed microemulsions were stable. Moreover, the developed microemulsions had direct effects on B16-F10 mouse melanoma cells. The anti-melanogenesis activities of dA-containing microemulsions were evidently better than that of the free dA group. The results demonstrated that the developed microemulsion encapsulating dA may allow the use of deoxyArbutin instead of hydroquinone to treat dermal hyperpigmentation disorders in the future. |
format | Online Article Text |
id | pubmed-8658635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86586352021-12-10 Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin Chang, Nai-Fang Tsai, Feng-Jie Zheng, Ya-Min Huang, Wei-Hsiang Lin, Chih-Chien Int J Mol Sci Article DeoxyArbutin (dA) is a tyrosinase inhibitor that has effective skin-lightening activity and has no obvious cytotoxicity toward melanocytes. With the aim of directly evaluating the effects of microemulsions containing dA on cells, we developed oil-in-water (O/W) microemulsions with relatively lower cytotoxicities by using polysorbate-series surfactants. Measurement of the transparent properties and particle size analysis at different storage time periods revealed that the developed microemulsions were stable. Moreover, the developed microemulsions had direct effects on B16-F10 mouse melanoma cells. The anti-melanogenesis activities of dA-containing microemulsions were evidently better than that of the free dA group. The results demonstrated that the developed microemulsion encapsulating dA may allow the use of deoxyArbutin instead of hydroquinone to treat dermal hyperpigmentation disorders in the future. MDPI 2021-12-03 /pmc/articles/PMC8658635/ /pubmed/34884914 http://dx.doi.org/10.3390/ijms222313110 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chang, Nai-Fang Tsai, Feng-Jie Zheng, Ya-Min Huang, Wei-Hsiang Lin, Chih-Chien Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin |
title | Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin |
title_full | Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin |
title_fullStr | Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin |
title_full_unstemmed | Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin |
title_short | Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin |
title_sort | using a cellular system to directly assess the effects of cosmetic microemulsion encapsulated deoxyarbutin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658635/ https://www.ncbi.nlm.nih.gov/pubmed/34884914 http://dx.doi.org/10.3390/ijms222313110 |
work_keys_str_mv | AT changnaifang usingacellularsystemtodirectlyassesstheeffectsofcosmeticmicroemulsionencapsulateddeoxyarbutin AT tsaifengjie usingacellularsystemtodirectlyassesstheeffectsofcosmeticmicroemulsionencapsulateddeoxyarbutin AT zhengyamin usingacellularsystemtodirectlyassesstheeffectsofcosmeticmicroemulsionencapsulateddeoxyarbutin AT huangweihsiang usingacellularsystemtodirectlyassesstheeffectsofcosmeticmicroemulsionencapsulateddeoxyarbutin AT linchihchien usingacellularsystemtodirectlyassesstheeffectsofcosmeticmicroemulsionencapsulateddeoxyarbutin |