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Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin

DeoxyArbutin (dA) is a tyrosinase inhibitor that has effective skin-lightening activity and has no obvious cytotoxicity toward melanocytes. With the aim of directly evaluating the effects of microemulsions containing dA on cells, we developed oil-in-water (O/W) microemulsions with relatively lower c...

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Detalles Bibliográficos
Autores principales: Chang, Nai-Fang, Tsai, Feng-Jie, Zheng, Ya-Min, Huang, Wei-Hsiang, Lin, Chih-Chien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658635/
https://www.ncbi.nlm.nih.gov/pubmed/34884914
http://dx.doi.org/10.3390/ijms222313110
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author Chang, Nai-Fang
Tsai, Feng-Jie
Zheng, Ya-Min
Huang, Wei-Hsiang
Lin, Chih-Chien
author_facet Chang, Nai-Fang
Tsai, Feng-Jie
Zheng, Ya-Min
Huang, Wei-Hsiang
Lin, Chih-Chien
author_sort Chang, Nai-Fang
collection PubMed
description DeoxyArbutin (dA) is a tyrosinase inhibitor that has effective skin-lightening activity and has no obvious cytotoxicity toward melanocytes. With the aim of directly evaluating the effects of microemulsions containing dA on cells, we developed oil-in-water (O/W) microemulsions with relatively lower cytotoxicities by using polysorbate-series surfactants. Measurement of the transparent properties and particle size analysis at different storage time periods revealed that the developed microemulsions were stable. Moreover, the developed microemulsions had direct effects on B16-F10 mouse melanoma cells. The anti-melanogenesis activities of dA-containing microemulsions were evidently better than that of the free dA group. The results demonstrated that the developed microemulsion encapsulating dA may allow the use of deoxyArbutin instead of hydroquinone to treat dermal hyperpigmentation disorders in the future.
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spelling pubmed-86586352021-12-10 Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin Chang, Nai-Fang Tsai, Feng-Jie Zheng, Ya-Min Huang, Wei-Hsiang Lin, Chih-Chien Int J Mol Sci Article DeoxyArbutin (dA) is a tyrosinase inhibitor that has effective skin-lightening activity and has no obvious cytotoxicity toward melanocytes. With the aim of directly evaluating the effects of microemulsions containing dA on cells, we developed oil-in-water (O/W) microemulsions with relatively lower cytotoxicities by using polysorbate-series surfactants. Measurement of the transparent properties and particle size analysis at different storage time periods revealed that the developed microemulsions were stable. Moreover, the developed microemulsions had direct effects on B16-F10 mouse melanoma cells. The anti-melanogenesis activities of dA-containing microemulsions were evidently better than that of the free dA group. The results demonstrated that the developed microemulsion encapsulating dA may allow the use of deoxyArbutin instead of hydroquinone to treat dermal hyperpigmentation disorders in the future. MDPI 2021-12-03 /pmc/articles/PMC8658635/ /pubmed/34884914 http://dx.doi.org/10.3390/ijms222313110 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Nai-Fang
Tsai, Feng-Jie
Zheng, Ya-Min
Huang, Wei-Hsiang
Lin, Chih-Chien
Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin
title Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin
title_full Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin
title_fullStr Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin
title_full_unstemmed Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin
title_short Using a Cellular System to Directly Assess the Effects of Cosmetic Microemulsion Encapsulated DeoxyArbutin
title_sort using a cellular system to directly assess the effects of cosmetic microemulsion encapsulated deoxyarbutin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658635/
https://www.ncbi.nlm.nih.gov/pubmed/34884914
http://dx.doi.org/10.3390/ijms222313110
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