Cargando…

Prognostic Role of Subcutaneous and Visceral Adiposity in Hospitalized Octogenarians with COVID-19

Background: We investigated the prognostic significance of visceral and subcutaneous adiposity in octogenarians with COVID-19. Methods: This paper presents a monocentric retrospective study that was conducted in acute geriatric wards with 64 hospitalized patients aged 80+ who had a diagnosis of COVI...

Descripción completa

Detalles Bibliográficos
Autores principales: Scheffler, Max, Genton, Laurence, Graf, Christophe E., Remuinan, Jorge, Gold, Gabriel, Zekry, Dina, Serratrice, Christine, Herrmann, François R., Mendes, Aline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658645/
https://www.ncbi.nlm.nih.gov/pubmed/34884199
http://dx.doi.org/10.3390/jcm10235500
_version_ 1784612779246747648
author Scheffler, Max
Genton, Laurence
Graf, Christophe E.
Remuinan, Jorge
Gold, Gabriel
Zekry, Dina
Serratrice, Christine
Herrmann, François R.
Mendes, Aline
author_facet Scheffler, Max
Genton, Laurence
Graf, Christophe E.
Remuinan, Jorge
Gold, Gabriel
Zekry, Dina
Serratrice, Christine
Herrmann, François R.
Mendes, Aline
author_sort Scheffler, Max
collection PubMed
description Background: We investigated the prognostic significance of visceral and subcutaneous adiposity in octogenarians with COVID-19. Methods: This paper presents a monocentric retrospective study that was conducted in acute geriatric wards with 64 hospitalized patients aged 80+ who had a diagnosis of COVID-19 and who underwent a chest CT scan. A quantification of the subcutaneous, visceral, and total fat areas was performed after segmentations on the first abdominal slice caudal to the deepest pleural recess on a soft-tissue window setting. Logistic regression models were applied to investigate the association with in-hospital mortality and the extent of COVID-19 pneumonia. Results: The patients had a mean age of 86.4 ± 6.0 years, and 46.9% were male, with a mean BMI of 24.1 ± 4.4Kg/m(2) and mortality rate of 32.8%. A higher subcutaneous fat area had a protective effect against mortality (OR 0.416; 0.183–0.944 95% CI; p = 0.036), which remained significant after adjustments for age, sex, and BMI (OR 0.231; 0.071–0.751 95% CI; p = 0.015). Inversely, higher abdominal circumference, total fat area, subcutaneous fat area, and visceral fat were associated with worse COVID-19 pneumonia, with the latter presenting the strongest association after adjustments for age, sex, and BMI (OR 2.862; 1.523–5.379 95% CI; p = 0.001). Conclusion: Subcutaneous and visceral fat areas measured on chest CT scans were associated with prognosis in octogenarians with COVID-19.
format Online
Article
Text
id pubmed-8658645
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86586452021-12-10 Prognostic Role of Subcutaneous and Visceral Adiposity in Hospitalized Octogenarians with COVID-19 Scheffler, Max Genton, Laurence Graf, Christophe E. Remuinan, Jorge Gold, Gabriel Zekry, Dina Serratrice, Christine Herrmann, François R. Mendes, Aline J Clin Med Article Background: We investigated the prognostic significance of visceral and subcutaneous adiposity in octogenarians with COVID-19. Methods: This paper presents a monocentric retrospective study that was conducted in acute geriatric wards with 64 hospitalized patients aged 80+ who had a diagnosis of COVID-19 and who underwent a chest CT scan. A quantification of the subcutaneous, visceral, and total fat areas was performed after segmentations on the first abdominal slice caudal to the deepest pleural recess on a soft-tissue window setting. Logistic regression models were applied to investigate the association with in-hospital mortality and the extent of COVID-19 pneumonia. Results: The patients had a mean age of 86.4 ± 6.0 years, and 46.9% were male, with a mean BMI of 24.1 ± 4.4Kg/m(2) and mortality rate of 32.8%. A higher subcutaneous fat area had a protective effect against mortality (OR 0.416; 0.183–0.944 95% CI; p = 0.036), which remained significant after adjustments for age, sex, and BMI (OR 0.231; 0.071–0.751 95% CI; p = 0.015). Inversely, higher abdominal circumference, total fat area, subcutaneous fat area, and visceral fat were associated with worse COVID-19 pneumonia, with the latter presenting the strongest association after adjustments for age, sex, and BMI (OR 2.862; 1.523–5.379 95% CI; p = 0.001). Conclusion: Subcutaneous and visceral fat areas measured on chest CT scans were associated with prognosis in octogenarians with COVID-19. MDPI 2021-11-24 /pmc/articles/PMC8658645/ /pubmed/34884199 http://dx.doi.org/10.3390/jcm10235500 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scheffler, Max
Genton, Laurence
Graf, Christophe E.
Remuinan, Jorge
Gold, Gabriel
Zekry, Dina
Serratrice, Christine
Herrmann, François R.
Mendes, Aline
Prognostic Role of Subcutaneous and Visceral Adiposity in Hospitalized Octogenarians with COVID-19
title Prognostic Role of Subcutaneous and Visceral Adiposity in Hospitalized Octogenarians with COVID-19
title_full Prognostic Role of Subcutaneous and Visceral Adiposity in Hospitalized Octogenarians with COVID-19
title_fullStr Prognostic Role of Subcutaneous and Visceral Adiposity in Hospitalized Octogenarians with COVID-19
title_full_unstemmed Prognostic Role of Subcutaneous and Visceral Adiposity in Hospitalized Octogenarians with COVID-19
title_short Prognostic Role of Subcutaneous and Visceral Adiposity in Hospitalized Octogenarians with COVID-19
title_sort prognostic role of subcutaneous and visceral adiposity in hospitalized octogenarians with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658645/
https://www.ncbi.nlm.nih.gov/pubmed/34884199
http://dx.doi.org/10.3390/jcm10235500
work_keys_str_mv AT schefflermax prognosticroleofsubcutaneousandvisceraladiposityinhospitalizedoctogenarianswithcovid19
AT gentonlaurence prognosticroleofsubcutaneousandvisceraladiposityinhospitalizedoctogenarianswithcovid19
AT grafchristophee prognosticroleofsubcutaneousandvisceraladiposityinhospitalizedoctogenarianswithcovid19
AT remuinanjorge prognosticroleofsubcutaneousandvisceraladiposityinhospitalizedoctogenarianswithcovid19
AT goldgabriel prognosticroleofsubcutaneousandvisceraladiposityinhospitalizedoctogenarianswithcovid19
AT zekrydina prognosticroleofsubcutaneousandvisceraladiposityinhospitalizedoctogenarianswithcovid19
AT serratricechristine prognosticroleofsubcutaneousandvisceraladiposityinhospitalizedoctogenarianswithcovid19
AT herrmannfrancoisr prognosticroleofsubcutaneousandvisceraladiposityinhospitalizedoctogenarianswithcovid19
AT mendesaline prognosticroleofsubcutaneousandvisceraladiposityinhospitalizedoctogenarianswithcovid19