Cargando…

Structural Characterization of Ectodomain G Protein of Respiratory Syncytial Virus and Its Interaction with Heparan Sulfate: Multi-Spectroscopic and In Silico Studies Elucidating Host-Pathogen Interactions

The global burden of disease caused by a respiratory syncytial virus (RSV) is becoming more widely recognized in young children and adults. Heparan sulfate helps in attaching the virion through G protein with the host cell membrane. In this study, we examined the structural changes of ectodomain G p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hamza, Abu, Samad, Abdus, Imam, Md. Ali, Faizan, Md. Imam, Ahmed, Anwar, Almajhdi, Fahad N., Hussain, Tajamul, Islam, Asimul, Parveen, Shama
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658883/ https://www.ncbi.nlm.nih.gov/pubmed/34885979 http://dx.doi.org/10.3390/molecules26237398

Ejemplares similares

Mutation in the CX3C Motif of G Protein Disrupts Its Interaction with Heparan Sulfate: A Calorimetric, Spectroscopic, and Molecular Docking Study
por: Hamza, Abu, et al.
Publicado: (2022)

Structural Characterization and Binding Studies of the Ectodomain G Protein of Respiratory Syncytial Virus Reveal the Crucial Role of pH with Possible Implications in Host–Pathogen Interactions
por: Hamza, Abu, et al.
Publicado: (2021)

Structural Refolding and Thermal Stability of Myoglobin in the Presence of Mixture of Crowders: Importance of Various Interactions for Protein Stabilization in Crowded Conditions
por: Parray, Zahoor Ahmad, et al.
Publicado: (2021)

Effects of Ethylene Glycol on the Structure and Stability of Myoglobin Using Spectroscopic, Interaction, and In Silico Approaches: Monomer Is Different from Those of Its Polymers
por: Parray, Zahoor Ahmad, et al.
Publicado: (2020)

Multispectroscopic and Molecular Docking Insight into Elucidating the Interaction of Irisin with Rivastigmine Tartrate: A Combinational Therapy Approach to Fight Alzheimer’s Disease
por: Waseem, Rashid, et al.
Publicado: (2021)

Identification of the Key miRNAs and Genes Associated with the Regulation of Non-Small Cell Lung Cancer: A Network-Based Approach
por: Shafat, Zoya, et al.
Publicado: (2022)

Interactions Under Crowding Milieu: Chemical-Induced Denaturation of Myoglobin is Determined by the Extent of Heme Dissociation on Interaction with Crowders
por: Nasreen, Khalida, et al.
Publicado: (2020)

Elucidating the Consequences of Heparan Sulfate Binding by Heparanase 2
por: Gross-Cohen, Miriam, et al.
Publicado: (2021)

Elucidating the Interaction of Human Ferritin with Quercetin and Naringenin: Implication of Natural Products in Neurodegenerative Diseases: Molecular Docking and Dynamics Simulation Insight
por: Shamsi, Anas, et al.
Publicado: (2021)

Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction
por: Furini, Giulia, et al.
Publicado: (2019)

Biophysical Elucidation of Fibrillation Inhibition by Sugar Osmolytes in α-Lactalbumin: Multispectroscopic and Molecular Docking Approaches
por: Bashir, Sania, et al.
Publicado: (2020)

Elucidating the Structure, Dynamics, and Interaction of a Choline Chloride and Citric Acid Based Eutectic System by Spectroscopic and Molecular Modeling Investigations
por: Ali, Md Ackas, et al.
Publicado: (2023)

Elucidation of molecular interactions of theaflavin monogallate with camel milk lactoferrin: detailed spectroscopic and dynamic simulation studies
por: Khan, Mohd Shahnawaz, et al.
Publicado: (2021)

Interactions between heparan sulfate and proteins: the concept of specificity
por: Kreuger, Johan, et al.
Publicado: (2006)

Elucidating the Role of Santalol as a Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches
por: Ali, Nabeel, et al.
Publicado: (2022)

Global and local evolutionary dynamics of Dengue virus serotypes 1, 3, and 4
por: Islam, Arshi, et al.
Publicado: (2023)

Heparin Accelerates the Protein Aggregation via the Downhill Polymerization Mechanism: Multi-Spectroscopic Studies to Delineate the Implications on Proteinopathies
por: Ahanger, Ishfaq Ahmad, et al.
Publicado: (2021)

Interaction of polyethylene glycol with cytochrome c investigated via in vitro and in silico approaches
por: Parray, Zahoor Ahmad, et al.
Publicado: (2021)

Glossary of phytoconstituents: Can these be repurposed against SARS CoV-2? A quick in silico screening of various phytoconstituents from plant Glycyrrhiza glabra with SARS CoV-2 main protease
por: Hejazi, Iram Iqbal, et al.
Publicado: (2021)

Targeting heparan sulfate-protein interactions with oligosaccharides and monoclonal antibodies
por: Li, Miaomiao, et al.
Publicado: (2023)

Unraveling Binding Mechanism of Alzheimer’s Drug Rivastigmine Tartrate with Human Transferrin: Molecular Docking and Multi-Spectroscopic Approach towards Neurodegenerative Diseases
por: Shamsi, Anas, et al.
Publicado: (2019)

Elucidating the interaction of letrozole with human serum albumin by combination of spectroscopic and molecular modeling techniques
por: Bijari, Nooshin, et al.
Publicado: (2018)

Elucidating the Interactions of Fluoxetine with Human Transferrin Employing Spectroscopic, Calorimetric, and In Silico Approaches: Implications of a Potent Alzheimer’s Drug
por: Khan, Mohd Shahnawaz, et al.
Publicado: (2022)

Syndecan-1-Induced ECM Fiber Alignment Requires Integrin αvβ3 and Syndecan-1 Ectodomain and Heparan Sulfate Chains
por: Yang, Ning, et al.
Publicado: (2016)

Spectroscopic and Molecular Docking Investigation on the Interaction of Cumin Components with Plasma Protein: Assessment of the Comparative Interactions of Aldehyde and Alcohol with Human Serum Albumin
por: Ali, Mohd Sajid, et al.
Publicado: (2022)

Granulin-epithelin precursor interacts with heparan sulfate on liver cancer cells
por: Yip, Chi Wai, et al.
Publicado: (2014)

pH-dependent and dynamic interactions of cystatin C with heparan sulfate
por: Zhang, Xiaoxiao, et al.
Publicado: (2021)

Spike-heparan sulfate interactions in SARS-CoV-2 infection
por: Kearns, Fiona L., et al.
Publicado: (2022)

Heparan sulfates and heparan sulfate binding proteins in sepsis
por: Liao, Yi-En, et al.
Publicado: (2023)

Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression
por: Nagarajan, Arvindhan, et al.
Publicado: (2018)

Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions
por: Weiss, Ryan J., et al.
Publicado: (2015)

Ranaviruses Bind Cells from Different Species through Interaction with Heparan Sulfate
por: Ke, Fei, et al.
Publicado: (2019)

Heparan Sulfate: A Regulator of White Adipocyte Differentiation and of Vascular/Adipocyte Interactions
por: Sorrell, J. Michael, et al.
Publicado: (2022)

Profiling Heparan Sulfate‐Heavy Metal Ions Interaction Using Electrochemical Techniques
por: Shitrit, Ariel, et al.
Publicado: (2022)

Molecular determinants of the interaction between HSV-1 glycoprotein D and heparan sulfate
por: Gandy, Lauren A., et al.
Publicado: (2022)

Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient
por: Gude, Fabian, et al.
Publicado: (2023)

VSIG4 interaction with heparan sulfates inhibits VSIG4–complement binding
por: Ebstein, Sarah Y, et al.
Publicado: (2023)

Elucidating the Interactions Between Heparin/Heparan Sulfate and SARS-CoV-2-Related Proteins—An Important Strategy for Developing Novel Therapeutics for the COVID-19 Pandemic
por: Yu, Mingjia, et al.
Publicado: (2021)

Elucidation of Dietary Polyphenolics as Potential Inhibitor of Microtubule Affinity Regulating Kinase 4: In silico and In vitro Studies
por: Khan, Parvez, et al.
Publicado: (2017)

Size-Dependent Interplay of Volume Exclusion Versus Soft Interactions: Cytochrome c in Macromolecular Crowded Environment
por: Parray, Zahoor Ahmad, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_csjdflbmet554q93jojqn7249l