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Cobalt-Catalyzed Cyclization of 2-Bromobenzamides with Carbodiimides: A New Route for the Synthesis of 3-(Imino)isoindolin-1-ones
A novel synthetic pathway to approach 3-(imino)isoindolin-1-ones by the Co-catalyzed cyclization reaction of 2-bromobenzamides with carbodiimides has been developed. This catalytic reaction can tolerate a variety of substituents and provide corresponding products in moderate yields for most cases. A...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658922/ https://www.ncbi.nlm.nih.gov/pubmed/34885794 http://dx.doi.org/10.3390/molecules26237212 |
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author | Aman, Hasil Huang, Yu-Chiao Liu, Yu-Hao Tsai, Yu-Lin Kim, Min Hsieh, Jen-Chieh Chuang, Gary Jing |
author_facet | Aman, Hasil Huang, Yu-Chiao Liu, Yu-Hao Tsai, Yu-Lin Kim, Min Hsieh, Jen-Chieh Chuang, Gary Jing |
author_sort | Aman, Hasil |
collection | PubMed |
description | A novel synthetic pathway to approach 3-(imino)isoindolin-1-ones by the Co-catalyzed cyclization reaction of 2-bromobenzamides with carbodiimides has been developed. This catalytic reaction can tolerate a variety of substituents and provide corresponding products in moderate yields for most cases. According to the literature, the reaction mechanism is proposed through the formation of a five-membered aza-cobalacycle complex, which carries out the following reaction subsequence, including nucleophilic addition and substitution, to furnish the desired structures. |
format | Online Article Text |
id | pubmed-8658922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86589222021-12-10 Cobalt-Catalyzed Cyclization of 2-Bromobenzamides with Carbodiimides: A New Route for the Synthesis of 3-(Imino)isoindolin-1-ones Aman, Hasil Huang, Yu-Chiao Liu, Yu-Hao Tsai, Yu-Lin Kim, Min Hsieh, Jen-Chieh Chuang, Gary Jing Molecules Article A novel synthetic pathway to approach 3-(imino)isoindolin-1-ones by the Co-catalyzed cyclization reaction of 2-bromobenzamides with carbodiimides has been developed. This catalytic reaction can tolerate a variety of substituents and provide corresponding products in moderate yields for most cases. According to the literature, the reaction mechanism is proposed through the formation of a five-membered aza-cobalacycle complex, which carries out the following reaction subsequence, including nucleophilic addition and substitution, to furnish the desired structures. MDPI 2021-11-28 /pmc/articles/PMC8658922/ /pubmed/34885794 http://dx.doi.org/10.3390/molecules26237212 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Aman, Hasil Huang, Yu-Chiao Liu, Yu-Hao Tsai, Yu-Lin Kim, Min Hsieh, Jen-Chieh Chuang, Gary Jing Cobalt-Catalyzed Cyclization of 2-Bromobenzamides with Carbodiimides: A New Route for the Synthesis of 3-(Imino)isoindolin-1-ones |
title | Cobalt-Catalyzed Cyclization of 2-Bromobenzamides with Carbodiimides: A New Route for the Synthesis of 3-(Imino)isoindolin-1-ones |
title_full | Cobalt-Catalyzed Cyclization of 2-Bromobenzamides with Carbodiimides: A New Route for the Synthesis of 3-(Imino)isoindolin-1-ones |
title_fullStr | Cobalt-Catalyzed Cyclization of 2-Bromobenzamides with Carbodiimides: A New Route for the Synthesis of 3-(Imino)isoindolin-1-ones |
title_full_unstemmed | Cobalt-Catalyzed Cyclization of 2-Bromobenzamides with Carbodiimides: A New Route for the Synthesis of 3-(Imino)isoindolin-1-ones |
title_short | Cobalt-Catalyzed Cyclization of 2-Bromobenzamides with Carbodiimides: A New Route for the Synthesis of 3-(Imino)isoindolin-1-ones |
title_sort | cobalt-catalyzed cyclization of 2-bromobenzamides with carbodiimides: a new route for the synthesis of 3-(imino)isoindolin-1-ones |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658922/ https://www.ncbi.nlm.nih.gov/pubmed/34885794 http://dx.doi.org/10.3390/molecules26237212 |
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