Exploring Amantadine Derivatives as Urease Inhibitors: Molecular Docking and Structure–Activity Relationship (SAR) Studies

This article describes the design and synthesis of a series of novel amantadine-thiourea conjugates (3a–j) as Jack bean urease inhibitors. The synthesized hybrids were assayed for their in vitro urease inhibition. Accordingly, N-(adamantan-1-ylcarbamothioyl)octanamide (3j) possessing a 7-carbon alky...

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Detalles Bibliográficos
Autores principales: Ahmed, Atteeque, Saeed, Aamer, Ali, Omar M., El-Bahy, Zeinhom M., Channar, Pervaiz Ali, Khurshid, Asma, Tehzeeb, Arfa, Ashraf, Zaman, Raza, Hussain, Ul-Hamid, Anwar, Hassan, Mubashir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658948/
https://www.ncbi.nlm.nih.gov/pubmed/34885728
http://dx.doi.org/10.3390/molecules26237150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658948/
https://www.ncbi.nlm.nih.gov/pubmed/34885728
http://dx.doi.org/10.3390/molecules26237150

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