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Effects of Prenatal Exposure to Aflatoxin B1: A Review
Aflatoxins are mycotoxins produced as secondary fungal metabolites. Among them, aflatoxin B1 (AFB1) stands out due to its genotoxic and mutagenic potential, being a potent initiator of carcinogenesis. In this review, the outcomes from the published literature in the past 10 years on the effects of A...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659025/ https://www.ncbi.nlm.nih.gov/pubmed/34885894 http://dx.doi.org/10.3390/molecules26237312 |
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author | da Silva, João Victor Batista de Oliveira, Carlos Augusto Fernandes Ramalho, Leandra Náira Zambelli |
author_facet | da Silva, João Victor Batista de Oliveira, Carlos Augusto Fernandes Ramalho, Leandra Náira Zambelli |
author_sort | da Silva, João Victor Batista |
collection | PubMed |
description | Aflatoxins are mycotoxins produced as secondary fungal metabolites. Among them, aflatoxin B1 (AFB1) stands out due to its genotoxic and mutagenic potential, being a potent initiator of carcinogenesis. In this review, the outcomes from the published literature in the past 10 years on the effects of AFB1 pathophysiological mechanisms on embryological and fetal development are discussed. In several animal species, including humans, AFB1 has a teratogenic effect(,) resulting in bone malformations, visceral anomalies, lesions in several organs, and behavioral and reproductive changes, in addition to low birth weight. The mutagenic capacity of AFB1 in prenatal life is greater than in adults, indicating that when exposure occurs in the womb, the risk of the development of neoplasms is higher. Studies conducted in humans indicate that the exposure to this mycotoxin during pregnancy is associated with low birth weight, decreased head circumference, and DNA hypermethylation. However, as the actual impacts on humans are still unclear, the importance of this issue cannot be overemphasized and studies on the matter are essential. |
format | Online Article Text |
id | pubmed-8659025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86590252021-12-10 Effects of Prenatal Exposure to Aflatoxin B1: A Review da Silva, João Victor Batista de Oliveira, Carlos Augusto Fernandes Ramalho, Leandra Náira Zambelli Molecules Review Aflatoxins are mycotoxins produced as secondary fungal metabolites. Among them, aflatoxin B1 (AFB1) stands out due to its genotoxic and mutagenic potential, being a potent initiator of carcinogenesis. In this review, the outcomes from the published literature in the past 10 years on the effects of AFB1 pathophysiological mechanisms on embryological and fetal development are discussed. In several animal species, including humans, AFB1 has a teratogenic effect(,) resulting in bone malformations, visceral anomalies, lesions in several organs, and behavioral and reproductive changes, in addition to low birth weight. The mutagenic capacity of AFB1 in prenatal life is greater than in adults, indicating that when exposure occurs in the womb, the risk of the development of neoplasms is higher. Studies conducted in humans indicate that the exposure to this mycotoxin during pregnancy is associated with low birth weight, decreased head circumference, and DNA hypermethylation. However, as the actual impacts on humans are still unclear, the importance of this issue cannot be overemphasized and studies on the matter are essential. MDPI 2021-12-02 /pmc/articles/PMC8659025/ /pubmed/34885894 http://dx.doi.org/10.3390/molecules26237312 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review da Silva, João Victor Batista de Oliveira, Carlos Augusto Fernandes Ramalho, Leandra Náira Zambelli Effects of Prenatal Exposure to Aflatoxin B1: A Review |
title | Effects of Prenatal Exposure to Aflatoxin B1: A Review |
title_full | Effects of Prenatal Exposure to Aflatoxin B1: A Review |
title_fullStr | Effects of Prenatal Exposure to Aflatoxin B1: A Review |
title_full_unstemmed | Effects of Prenatal Exposure to Aflatoxin B1: A Review |
title_short | Effects of Prenatal Exposure to Aflatoxin B1: A Review |
title_sort | effects of prenatal exposure to aflatoxin b1: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659025/ https://www.ncbi.nlm.nih.gov/pubmed/34885894 http://dx.doi.org/10.3390/molecules26237312 |
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