Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 3

17β-Hydroxysteroid dehydrogenase type 3 (17β-HSD3) is expressed at high levels in testes and seminal vesicles; it is also present in prostate tissue and involved in gonadal and non-gonadal testosterone biosynthesis. The enzyme is membrane-bound, and a crystal structure is not yet available. Selectiv...

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Detalles Bibliográficos
Autores principales: Vicker, Nigel, Bailey, Helen V., Day, Joanna M., Mahon, Mary F., Smith, Andrew, Tutill, Helena J., Purohit, Atul, Potter, Barry V. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659031/
https://www.ncbi.nlm.nih.gov/pubmed/34885749
http://dx.doi.org/10.3390/molecules26237166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659031/
https://www.ncbi.nlm.nih.gov/pubmed/34885749
http://dx.doi.org/10.3390/molecules26237166

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