Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities

Three novel monoterpenoid indole alkaloids gardflorine A (1), gardflorine B (2), and gardflorine C (3) were isolated from the leaves of Gardneria multiflora. Their structures, including absolute configurations, were established on the basis of spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and ci...

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Autores principales: Zhang, Sheng-Yuan, Li, Zi-Wei, Xu, Jie, Chen, Qiu-Ling, Song, Min, Zhang, Qing-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659093/
https://www.ncbi.nlm.nih.gov/pubmed/34885772
http://dx.doi.org/10.3390/molecules26237191
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author Zhang, Sheng-Yuan
Li, Zi-Wei
Xu, Jie
Chen, Qiu-Ling
Song, Min
Zhang, Qing-Wen
author_facet Zhang, Sheng-Yuan
Li, Zi-Wei
Xu, Jie
Chen, Qiu-Ling
Song, Min
Zhang, Qing-Wen
author_sort Zhang, Sheng-Yuan
collection PubMed
description Three novel monoterpenoid indole alkaloids gardflorine A (1), gardflorine B (2), and gardflorine C (3) were isolated from the leaves of Gardneria multiflora. Their structures, including absolute configurations, were established on the basis of spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and circular dichroism experiments. All the compounds were evaluated for their vasorelaxant and acetylcholinesterase (AChE) inhibitory activities. Compound 1 exhibited potent vasorelaxant activity, with an EC(50) value of 8.7 μM, and compounds 2 and 3 showed moderate acetylcholinesterase (AChE) inhibitory activities, with IC(50) values of 26.8 and 29.2 μM, respectively.
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spelling pubmed-86590932021-12-10 Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities Zhang, Sheng-Yuan Li, Zi-Wei Xu, Jie Chen, Qiu-Ling Song, Min Zhang, Qing-Wen Molecules Article Three novel monoterpenoid indole alkaloids gardflorine A (1), gardflorine B (2), and gardflorine C (3) were isolated from the leaves of Gardneria multiflora. Their structures, including absolute configurations, were established on the basis of spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and circular dichroism experiments. All the compounds were evaluated for their vasorelaxant and acetylcholinesterase (AChE) inhibitory activities. Compound 1 exhibited potent vasorelaxant activity, with an EC(50) value of 8.7 μM, and compounds 2 and 3 showed moderate acetylcholinesterase (AChE) inhibitory activities, with IC(50) values of 26.8 and 29.2 μM, respectively. MDPI 2021-11-27 /pmc/articles/PMC8659093/ /pubmed/34885772 http://dx.doi.org/10.3390/molecules26237191 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Sheng-Yuan
Li, Zi-Wei
Xu, Jie
Chen, Qiu-Ling
Song, Min
Zhang, Qing-Wen
Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities
title Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities
title_full Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities
title_fullStr Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities
title_full_unstemmed Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities
title_short Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities
title_sort discovery of three new monoterpenoid indole alkaloids from the leaves of gardneria multiflora and their vasorelaxant and ache inhibitory activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659093/
https://www.ncbi.nlm.nih.gov/pubmed/34885772
http://dx.doi.org/10.3390/molecules26237191
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