Effect of S–Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel N-acylhydrazone Derivatives at the Adenosine A(2A) Receptor

In this work, we evaluated the conformational effect promoted by the isosteric exchange of sulfur by selenium in the heteroaromatic ring of new N-acylhydrazone (NAH) derivatives (3–8, 13, 14), analogues of the cardioactive compounds LASSBio-294 (1) and LASSBio-785 (2). NMR spectra analysis demonstra...

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Detalles Bibliográficos
Autores principales: Pedreira, Júlia Galvez Bulhões, Silva, Rafaela Ribeiro, Noël, François G., Barreiro, Eliezer J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659164/
https://www.ncbi.nlm.nih.gov/pubmed/34885946
http://dx.doi.org/10.3390/molecules26237364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659164/
https://www.ncbi.nlm.nih.gov/pubmed/34885946
http://dx.doi.org/10.3390/molecules26237364

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