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Effect of S–Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel N-acylhydrazone Derivatives at the Adenosine A(2A) Receptor
In this work, we evaluated the conformational effect promoted by the isosteric exchange of sulfur by selenium in the heteroaromatic ring of new N-acylhydrazone (NAH) derivatives (3–8, 13, 14), analogues of the cardioactive compounds LASSBio-294 (1) and LASSBio-785 (2). NMR spectra analysis demonstra...
Autores principales: | Pedreira, Júlia Galvez Bulhões, Silva, Rafaela Ribeiro, Noël, François G., Barreiro, Eliezer J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659164/ https://www.ncbi.nlm.nih.gov/pubmed/34885946 http://dx.doi.org/10.3390/molecules26237364 |
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