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A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis
A preliminary design of customized antibiotic-loaded poly-methyl-methacrylate (ALPMMA) spacer characterized by an appropriate footprint according to the specific patient’s anatomy and a reliable mechanical response to severe functional loads (i.e., level walking and 45° bent knee) is reported. The t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659215/ https://www.ncbi.nlm.nih.gov/pubmed/34883568 http://dx.doi.org/10.3390/polym13234065 |
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author | Balato, Marco Petrarca, Carlo Quercia, Antonio Riccio, Aniello Sellitto, Andrea Campi, Jessica Borriello, Anna Zarrelli, Mauro Balato, Giovanni |
author_facet | Balato, Marco Petrarca, Carlo Quercia, Antonio Riccio, Aniello Sellitto, Andrea Campi, Jessica Borriello, Anna Zarrelli, Mauro Balato, Giovanni |
author_sort | Balato, Marco |
collection | PubMed |
description | A preliminary design of customized antibiotic-loaded poly-methyl-methacrylate (ALPMMA) spacer characterized by an appropriate footprint according to the specific patient’s anatomy and a reliable mechanical response to severe functional loads (i.e., level walking and 45° bent knee) is reported. The targeted virtual prototyping process takes origin from a novel patented 3D geometrical conceptualization characterized by added customization features and it is validated by a preliminary FEM-based analysis. Mechanical and thermomechanical properties of the antibiotic-doped orthopedic PMMA cement, which will be used for the future prototype manufacturing, were measured experimentally by testing samples taken during a real day-running orthopedic surgery and manufactured according to the surgeon protocol. FEM analysis results indicate that small area is subjected to intensive stresses, validating the proposed geometry from the mechanical point of view, under the two loading scenarios, moreover the value of safety margins results positive, and this is representative of the lower stress magnitude compared to the critical material limits. The experimental data confirm that the presence of antibiotic will last during the surgeon period moreover, the temperature dependent modulus of the bone cement is slightly affected by the body range temperature whereas it will drastically drop for higher temperature out the range of interest. A complete customization, according to a patient anatomy, and the corresponding real prototype spacer will be manufactured by 3D printing techniques, and it will be validated by destructive testing during the second stage of this activity before commercialization. |
format | Online Article Text |
id | pubmed-8659215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86592152021-12-10 A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis Balato, Marco Petrarca, Carlo Quercia, Antonio Riccio, Aniello Sellitto, Andrea Campi, Jessica Borriello, Anna Zarrelli, Mauro Balato, Giovanni Polymers (Basel) Article A preliminary design of customized antibiotic-loaded poly-methyl-methacrylate (ALPMMA) spacer characterized by an appropriate footprint according to the specific patient’s anatomy and a reliable mechanical response to severe functional loads (i.e., level walking and 45° bent knee) is reported. The targeted virtual prototyping process takes origin from a novel patented 3D geometrical conceptualization characterized by added customization features and it is validated by a preliminary FEM-based analysis. Mechanical and thermomechanical properties of the antibiotic-doped orthopedic PMMA cement, which will be used for the future prototype manufacturing, were measured experimentally by testing samples taken during a real day-running orthopedic surgery and manufactured according to the surgeon protocol. FEM analysis results indicate that small area is subjected to intensive stresses, validating the proposed geometry from the mechanical point of view, under the two loading scenarios, moreover the value of safety margins results positive, and this is representative of the lower stress magnitude compared to the critical material limits. The experimental data confirm that the presence of antibiotic will last during the surgeon period moreover, the temperature dependent modulus of the bone cement is slightly affected by the body range temperature whereas it will drastically drop for higher temperature out the range of interest. A complete customization, according to a patient anatomy, and the corresponding real prototype spacer will be manufactured by 3D printing techniques, and it will be validated by destructive testing during the second stage of this activity before commercialization. MDPI 2021-11-23 /pmc/articles/PMC8659215/ /pubmed/34883568 http://dx.doi.org/10.3390/polym13234065 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Balato, Marco Petrarca, Carlo Quercia, Antonio Riccio, Aniello Sellitto, Andrea Campi, Jessica Borriello, Anna Zarrelli, Mauro Balato, Giovanni A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis |
title | A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis |
title_full | A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis |
title_fullStr | A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis |
title_full_unstemmed | A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis |
title_short | A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis |
title_sort | customized knee antibiotic-loaded pmma spacer: a preliminary design analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659215/ https://www.ncbi.nlm.nih.gov/pubmed/34883568 http://dx.doi.org/10.3390/polym13234065 |
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