Cargando…

A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis

A preliminary design of customized antibiotic-loaded poly-methyl-methacrylate (ALPMMA) spacer characterized by an appropriate footprint according to the specific patient’s anatomy and a reliable mechanical response to severe functional loads (i.e., level walking and 45° bent knee) is reported. The t...

Descripción completa

Detalles Bibliográficos
Autores principales: Balato, Marco, Petrarca, Carlo, Quercia, Antonio, Riccio, Aniello, Sellitto, Andrea, Campi, Jessica, Borriello, Anna, Zarrelli, Mauro, Balato, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659215/
https://www.ncbi.nlm.nih.gov/pubmed/34883568
http://dx.doi.org/10.3390/polym13234065
_version_ 1784612911372566528
author Balato, Marco
Petrarca, Carlo
Quercia, Antonio
Riccio, Aniello
Sellitto, Andrea
Campi, Jessica
Borriello, Anna
Zarrelli, Mauro
Balato, Giovanni
author_facet Balato, Marco
Petrarca, Carlo
Quercia, Antonio
Riccio, Aniello
Sellitto, Andrea
Campi, Jessica
Borriello, Anna
Zarrelli, Mauro
Balato, Giovanni
author_sort Balato, Marco
collection PubMed
description A preliminary design of customized antibiotic-loaded poly-methyl-methacrylate (ALPMMA) spacer characterized by an appropriate footprint according to the specific patient’s anatomy and a reliable mechanical response to severe functional loads (i.e., level walking and 45° bent knee) is reported. The targeted virtual prototyping process takes origin from a novel patented 3D geometrical conceptualization characterized by added customization features and it is validated by a preliminary FEM-based analysis. Mechanical and thermomechanical properties of the antibiotic-doped orthopedic PMMA cement, which will be used for the future prototype manufacturing, were measured experimentally by testing samples taken during a real day-running orthopedic surgery and manufactured according to the surgeon protocol. FEM analysis results indicate that small area is subjected to intensive stresses, validating the proposed geometry from the mechanical point of view, under the two loading scenarios, moreover the value of safety margins results positive, and this is representative of the lower stress magnitude compared to the critical material limits. The experimental data confirm that the presence of antibiotic will last during the surgeon period moreover, the temperature dependent modulus of the bone cement is slightly affected by the body range temperature whereas it will drastically drop for higher temperature out the range of interest. A complete customization, according to a patient anatomy, and the corresponding real prototype spacer will be manufactured by 3D printing techniques, and it will be validated by destructive testing during the second stage of this activity before commercialization.
format Online
Article
Text
id pubmed-8659215
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86592152021-12-10 A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis Balato, Marco Petrarca, Carlo Quercia, Antonio Riccio, Aniello Sellitto, Andrea Campi, Jessica Borriello, Anna Zarrelli, Mauro Balato, Giovanni Polymers (Basel) Article A preliminary design of customized antibiotic-loaded poly-methyl-methacrylate (ALPMMA) spacer characterized by an appropriate footprint according to the specific patient’s anatomy and a reliable mechanical response to severe functional loads (i.e., level walking and 45° bent knee) is reported. The targeted virtual prototyping process takes origin from a novel patented 3D geometrical conceptualization characterized by added customization features and it is validated by a preliminary FEM-based analysis. Mechanical and thermomechanical properties of the antibiotic-doped orthopedic PMMA cement, which will be used for the future prototype manufacturing, were measured experimentally by testing samples taken during a real day-running orthopedic surgery and manufactured according to the surgeon protocol. FEM analysis results indicate that small area is subjected to intensive stresses, validating the proposed geometry from the mechanical point of view, under the two loading scenarios, moreover the value of safety margins results positive, and this is representative of the lower stress magnitude compared to the critical material limits. The experimental data confirm that the presence of antibiotic will last during the surgeon period moreover, the temperature dependent modulus of the bone cement is slightly affected by the body range temperature whereas it will drastically drop for higher temperature out the range of interest. A complete customization, according to a patient anatomy, and the corresponding real prototype spacer will be manufactured by 3D printing techniques, and it will be validated by destructive testing during the second stage of this activity before commercialization. MDPI 2021-11-23 /pmc/articles/PMC8659215/ /pubmed/34883568 http://dx.doi.org/10.3390/polym13234065 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Balato, Marco
Petrarca, Carlo
Quercia, Antonio
Riccio, Aniello
Sellitto, Andrea
Campi, Jessica
Borriello, Anna
Zarrelli, Mauro
Balato, Giovanni
A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis
title A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis
title_full A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis
title_fullStr A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis
title_full_unstemmed A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis
title_short A Customized Knee Antibiotic-Loaded PMMA Spacer: A Preliminary Design Analysis
title_sort customized knee antibiotic-loaded pmma spacer: a preliminary design analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659215/
https://www.ncbi.nlm.nih.gov/pubmed/34883568
http://dx.doi.org/10.3390/polym13234065
work_keys_str_mv AT balatomarco acustomizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT petrarcacarlo acustomizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT querciaantonio acustomizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT riccioaniello acustomizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT sellittoandrea acustomizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT campijessica acustomizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT borrielloanna acustomizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT zarrellimauro acustomizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT balatogiovanni acustomizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT balatomarco customizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT petrarcacarlo customizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT querciaantonio customizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT riccioaniello customizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT sellittoandrea customizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT campijessica customizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT borrielloanna customizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT zarrellimauro customizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis
AT balatogiovanni customizedkneeantibioticloadedpmmaspacerapreliminarydesignanalysis