Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts

A novel series of 1-[3-{3,5-bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone oximes 3a–h and related quaternary ammonium salts 4a–h were prepared as candidate antineoplastic agents. Evaluation against neoplastic Ca9-22, HSC-2 and HSC-4 cells revealed the compounds in series 3 and 4 to...

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Detalles Bibliográficos
Autores principales: Roayapalley, Praveen K., Dimmock, Jonathan R., Contreras, Lisett, Balderrama, Karol S., Aguilera, Renato J., Sakagami, Hiroshi, Amano, Shigeru, Sharma, Rajendra K., Das, Umashankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659243/
https://www.ncbi.nlm.nih.gov/pubmed/34885719
http://dx.doi.org/10.3390/molecules26237132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659243/
https://www.ncbi.nlm.nih.gov/pubmed/34885719
http://dx.doi.org/10.3390/molecules26237132

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