Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes

Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of unsaturated bonds with simultaneous addition of trifluoromethyl group along with o...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Bo, Escorihuela, Jorge, Han, Jianlin, Fustero, Santos, Barrio, Pablo, Sodeoka, Mikiko, Kawamura, Shintaro, Sorochinsky, Alexander, Soloshonok, Vadim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659293/
https://www.ncbi.nlm.nih.gov/pubmed/34885802
http://dx.doi.org/10.3390/molecules26237221
Descripción
Sumario:Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of unsaturated bonds with simultaneous addition of trifluoromethyl group along with other substituents is currently one of the most attractive methods undergoing wide-ranging development. In this review article, we discuss the most significant contributions made in this area during the last decade (2012−2021). The reactions reviewed in this work include chloro-, bromo-, iodo-, fluoro- and cyano-trifluoromethylation of alkenes and alkynes.

Ejemplares similares