Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes

Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of unsaturated bonds with simultaneous addition of trifluoromethyl group along with o...

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Autores principales: Fu, Bo, Escorihuela, Jorge, Han, Jianlin, Fustero, Santos, Barrio, Pablo, Sodeoka, Mikiko, Kawamura, Shintaro, Sorochinsky, Alexander, Soloshonok, Vadim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659293/
https://www.ncbi.nlm.nih.gov/pubmed/34885802
http://dx.doi.org/10.3390/molecules26237221
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author Fu, Bo
Escorihuela, Jorge
Han, Jianlin
Fustero, Santos
Barrio, Pablo
Sodeoka, Mikiko
Kawamura, Shintaro
Sorochinsky, Alexander
Soloshonok, Vadim A.
author_facet Fu, Bo
Escorihuela, Jorge
Han, Jianlin
Fustero, Santos
Barrio, Pablo
Sodeoka, Mikiko
Kawamura, Shintaro
Sorochinsky, Alexander
Soloshonok, Vadim A.
author_sort Fu, Bo
collection PubMed
description Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of unsaturated bonds with simultaneous addition of trifluoromethyl group along with other substituents is currently one of the most attractive methods undergoing wide-ranging development. In this review article, we discuss the most significant contributions made in this area during the last decade (2012−2021). The reactions reviewed in this work include chloro-, bromo-, iodo-, fluoro- and cyano-trifluoromethylation of alkenes and alkynes.
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spelling pubmed-86592932021-12-10 Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes Fu, Bo Escorihuela, Jorge Han, Jianlin Fustero, Santos Barrio, Pablo Sodeoka, Mikiko Kawamura, Shintaro Sorochinsky, Alexander Soloshonok, Vadim A. Molecules Review Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of unsaturated bonds with simultaneous addition of trifluoromethyl group along with other substituents is currently one of the most attractive methods undergoing wide-ranging development. In this review article, we discuss the most significant contributions made in this area during the last decade (2012−2021). The reactions reviewed in this work include chloro-, bromo-, iodo-, fluoro- and cyano-trifluoromethylation of alkenes and alkynes. MDPI 2021-11-28 /pmc/articles/PMC8659293/ /pubmed/34885802 http://dx.doi.org/10.3390/molecules26237221 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fu, Bo
Escorihuela, Jorge
Han, Jianlin
Fustero, Santos
Barrio, Pablo
Sodeoka, Mikiko
Kawamura, Shintaro
Sorochinsky, Alexander
Soloshonok, Vadim A.
Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes
title Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes
title_full Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes
title_fullStr Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes
title_full_unstemmed Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes
title_short Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes
title_sort recent advances on the halo- and cyano-trifluoromethylation of alkenes and alkynes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659293/
https://www.ncbi.nlm.nih.gov/pubmed/34885802
http://dx.doi.org/10.3390/molecules26237221
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